Systemic Lupus Erythematosus in a Multiethnic US Cohort (LUMINA): LXI. Value of C-Reactive Protein as a Marker of Disease Activity and Damage
Systemic Lupus Erythematosus in a Multiethnic US Cohort (LUMINA): LXI. Value of C-Reactive Protein as a Marker of Disease Activity and Damage
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DOI：
10.3899/jrheum.080175
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发表时间：
2008-12-01
影响因子：
3.9
通讯作者：
Alarcon, Graciela S.
中科院分区：
文献类型：
--
作者：
Bertoli, Ana M.;Vila, Luis M.;Alarcon, Graciela S.
客观的。确定通过高灵敏度 (hs) 测定法测量的 C 反应蛋白 (CRP) 是否是系统性红斑狼疮 (SLE) 11 疾病活动和损害的替代标志物。方法。对参加多种族队列（西班牙裔、非裔美国人和白种人）的 588 名 SLE 患者进行了研究。使用系统性狼疮活动修订版 (SLAM-R) 测量疾病活动性，并使用系统性狼疮国际合作诊所 (SLICC) 损伤指数 (SDI) 测量损伤。 hs-CRP通过免疫测定法测量。在入组时测量疾病活动度和 hs-CRP，并在最后一次访视时测量损害应计情况。通过单变量（皮尔逊相关）和多变量（线性回归）分析检查 hs-CRP 与 SLAM-R 和 SDI 的关联。通过 Spearman 相关性检查 hs-CRP 与 SLAM-R 和 SDI 的每个单独域的关联。结果。在单变量（r = 0.35，p < 0.001）和多变量（t = 7.11，系数 beta = 0.27，p < 0.001）分析中，hs-CRP 与 SLAM-R 相关。它还与 SLAM-R 的体质、眼睛、肺部、胃肠道、神经运动和实验室领域相关。在单变量分析中，hs-CRP 与 SDI 相关（r = 0.12，p = 0.004），但在多变量分析中则不然。当分析 SDI 的各个域时，hs-CRP 与肾、肺、心血管、肌肉骨骼和糖尿病域相关。结论。 hs-CRP 与疾病活动相关，但与总体损害无关；然而，它与损伤指数的特定领域相关。 hs-CRP 可能有助于监测疾病的病程并预测其中间结果，但需要进行连续 hs-CRP 测量的纵向研究来确定其临床价值。 （首次发布，2008 年 11 月 1 日；J Rheumatol 2008；35:2355-8；doi: 10.3899/jrheum.080175）
Objective. To determine whether C-reactive protein (CRP) measured by a high sensitivity (hs) assay is 11 Surrogate marker of disease activity and damage in systemic lupus erythematosus (SLE).Methods. Five hundred eighty-eight patients with SLE participating in a multiethnic cohort (Hispanic, African American, and Caucasian) were studied. Disease activity was measured with the Systemic Lupus Activity Measure-Revised (SLAM-R) and damage with the Systemic Lupus International Collaborating Clinics (SLICC) Damage Index (SDI). hs-CRP was measured by immunometric assay. Disease activity and hs-CRP were measured at enrollment and damage accrual at last visit. The association of hs-CRP with the SLAM-R and SDI was examined by univariable (Pearson's correlation) and multivariable (linear regression) analyses. The association of hs-CRP and each individual domain of the SLAM-R and SDI was examined by Spearman's correlation.Results. hs-CRP was associated with the SLAM-R in the Univariable (r = 0.35, p < 0.001) and multivariable (t = 7.11, coefficient beta = 0.27, p < 0.001) analyses. It also correlated with the constitutional, eye, pulmonary, gastrointestinal, neuromotor, and laboratory domains of the SLAM-R. hs-CRP was associated with the SDI (r = 0.12, p = 0.004) in the univariable analysis but not in the multivariable analysis. When the individual domains of the SDI were analyzed, hs-CRP correlated with the renal, pulmonary, cardiovascular, musculoskeletal, and diabetes domains.Conclusion. hs-CRP was associated with disease activity but not with overall damage accrual; however, it correlated with specific domains of the damage index. hs-CRP may be useful to monitor the course of the disease and predict its intermediate outcome, but longitudinal studies with serial hs-CRP measurements are necessary to define its clinical value. (First Release Nov 1 2008; J Rheumatol 2008;35:2355-8; doi: 10.3899/jrheum.080175)