Developmental pathways in depression: Multiple meanings, antecedents, and endpoints
Developmental pathways in depression: Multiple meanings, antecedents, and endpoints
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DOI：
10.1017/s095457940000732x
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发表时间：
1996-09-01
影响因子：
3.3
通讯作者：
Fombonne, E
中科院分区：
文献类型：
--
作者：
Harrington, R;Rutter, M;Fombonne, E
这篇文章概述了精神病学研究所过去30年来在儿童抑郁症方面所做的工作。这项工作从定义和测量的基本问题开始。流行病学研究表明，抑郁症状在儿童中相当常见，即使不具特异性，也是心理障碍的一个很好的指标。对流行病学和临床样本的进一步研究为抑郁综合征的有效性提供了一些证据。然而，这项工作也表明，这些抑郁综合征代表了一组不同的现象。因此，儿童重度抑郁障碍的有效性在纵向和家庭遗传学研究中得到进一步检验。这些研究支持这一概念的有效性，但证实了在发病时的发育阶段和与品行障碍的共病方面都存在异质性。我们的结论是，在儿童中可能存在几种不同类型的抑郁综合征，其中一些与成年后的抑郁障碍密切相关，但另一些可能更好地被概念化为另一种精神病理问题的一部分。
This article presents an overview of work conducted at the Institute of Psychiatry over the past 30 years on childhood depression. The work began with the basic question of definition and measurement. Epidemiological studies showed that depressive symptoms were quite common in children and were a good, if nonspecific, indicator of psychological disturbance. Further work in both epidemiological and clinical samples provided some evidence for the validity of a depressive syndrome. However, this work also showed that these depressive syndromes represented a heterogeneous group of phenomena. The validity of major depressive disorder in children was therefore tested further in longitudinal and family-genetic studies. These studies supported the validity of the concept but confirmed that there was heterogeneity in respect to both developmental stage at the time of onset and comorbidity with conduct disorder. We concluded that there are probably several different kinds of depressive syndromes in children, Some are strongly linked with depressive disorders in adulthood, but others are probably better conceptualized as part of another psychopathological problem altogether.