Molecular mechanism of peptide-induced pores in membranes
Molecular mechanism of peptide-induced pores in membranes
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DOI：
10.1103/physrevlett.92.198304
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发表时间：
2004-05-14
影响因子：
8.6
通讯作者：
Lee, MT
中科院分区：
文献类型：
--
作者：
Huang, HW;Chen, FY;Lee, MT
我们提出了一种物理机制，抗菌肽自发诱导膜中的稳定孔。肽与脂质双层的结合引起内应力或内部膜张力，其可以足够强以产生孔。与去污剂一样，肽对孔的边缘具有高亲和力。与边缘的结合降低了线张力并减少了引起内膜张力的肽的数量。因此，孔半径是稳定的。孔的形成类似于相变。
We suggest a physical mechanism by which antimicrobial peptides spontaneously induce stable pores in membranes. Peptide binding to a lipid bilayer causes an internal stress, or internal membrane tension, that can be sufficiently strong to create pores. Like detergents, peptides have a high affinity for the rim of the pore. Binding to the rims reduces the line tension and decreases the number of peptides causing the internal membrane tension. Consequently, the pore radius is stable. The pore formation resembles a phase transition.