Ghrelin counteracts salt-induced hypertension via promoting diuresis and renal nitric oxide production in Dahl rats
Ghrelin counteracts salt-induced hypertension via promoting diuresis and renal nitric oxide production in Dahl rats
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DOI：
10.1507/endocrj.ej12-0371
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发表时间：
2013-05-01
影响因子：
2
通讯作者：
Yada, Toshihiko
中科院分区：
文献类型：
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作者：
Aoki, Hirotaka;Nakata, Masanori;Yada, Toshihiko
胃饥饿素是生长激素促分泌素受体的内源性配体，在心脏、血管、肾脏等多种组织中均有表达。本研究旨在探讨长期给予胃饥饿素（10 nmol/kg，每天2次，腹腔注射）对Dahl盐敏感型高血压（DS）大鼠高盐（8.0% NaCl）饮食诱导的高血压的影响。采用尾袖带法测量收缩压（SBP）。在3周的治疗期间，高盐饮食与正常盐（0.3% NaCl）饮食相比，血压升高，且高血压部分但显著(P
Ghrelin is the endogenous ligand for the growth hormone-secretagogue receptor expressed in various tissues including the heart, blood vessels and kidney. This study sought to determine the effects of long-term treatment with ghrelin (10 nmol/kg, twice a day, intraperitoneally) on the hypertension induced by high salt (8.0% NaCl) diet in Dahl salt-sensitive hypertensive (DS) rats. Systolic blood pressure (SBP) was measured by a tail cuff method. During the treatment period for 3 weeks, high salt diet increased blood pressure compared to normal salt (0.3% NaCl) diet, and this hypertension was partly but significantly (P