Male Gonadal Toxicity
Male Gonadal Toxicity
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DOI：
10.1002/pbc.22004
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发表时间：
2009-08-01
影响因子：
3.2
通讯作者：
Meistrich, Marvin L.
中科院分区：
文献类型：
--
作者：
Meistrich, Marvin L.
化疗或放疗的癌症治疗会导致男性患者的性腺毒性。大多数考虑未来生育选择的终点是诱导可能可逆或不可逆的延长的无精子症。在青春期后患者中最容易观察到治疗的即时效果及其可逆性，但给予青春期前男性的相同治疗方案可能导致永久性无精子症。永久性无精子症的发生率与使用的特定药物及其剂量有关。最具破坏性的是烷化剂（特别是苯丁酸氮芥、甲基苄肼、环磷酰胺、美法仑和白消安）、顺铂和睾丸区域的辐射。儿科血液癌症2009;53：261-266。(C)2009威利-利斯公司
Cancer treatment with chemotherapy or radiotherapy causes gonadal toxicity in male patients. The endpoint of most concein for future reproductive options is the induction of piolonged azoospermia which may or may not be reversible. The immediate effects of therapy and its reversibility are most readily observed in Postpubertal patients, but the same antineoplastic regimens given to prepubertal males call induce permanent azoospermia. The probability of Permanent azoospermia is related to the specific agents used and their doses. The most damaging are alkylating agents (Particularly chlorambucil, procarbazine, cyclophosphamide, melphalan, and busulfan), cisplatin and radiation to the region of the testicles. Pediatr Blood Cancer 2009;53:261-266. (C) 2009 Wiley-Liss, Inc.