Redox state is a central modulator of the balance between self-renewal and differentiation in a dividing glial precursor cell
Redox state is a central modulator of the balance between self-renewal and differentiation in a dividing glial precursor cell
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DOI：
10.1073/pnas.170209797
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发表时间：
2000-08-29
影响因子：
11.1
通讯作者：
Noble, M
中科院分区：
文献类型：
--
作者：
Smith, J;Ladi, E;Noble, M
我们已经发现，细胞内的氧化还原状态似乎是一个必要的和足够的调制器之间的平衡，自我更新和分化的少突胶质细胞2型星形胶质细胞祖细胞。新鲜分离的祖细胞的细胞内氧化还原状态允许具有不同自我更新特征的细胞的前瞻性分离。氧化还原状态本身由改变自我更新和分化之间平衡的细胞外部信号分子调节：促进自我更新的生长因子导致祖细胞变得更加还原，而促进分化的信号分子导致祖细胞变得更加氧化。此外，这些细胞外源性信号分子的氧化还原作用的药理学拮抗剂拮抗它们对自我更新和分化的作用，表明调节这种平衡的细胞外源性信号分子会聚于氧化还原调节作为其效应机制的关键组分。
We have discovered that intracellular redox state appears to be a necessary and sufficient modulator of the balance between self-renewal and differentiation in dividing oligodendrocyte-type-2 astrocyte progenitor cells. The intracellular redox state of freshly isolated progenitors allows prospective isolation of cells with different self-renewal characteristics. Redox state is itself modulated by cell-extrinsic signaling molecules that alter the balance between self-renewal and differentiation: growth factors that promote self-renewal cause progenitors to become more reduced, while signaling molecules that promote differentiation cause progenitors to become more oxidized. Moreover, pharmacological antagonists of the redox effects of these cell-extrinsic signaling molecules antagonize their effects on self-renewal and differentiation, indicating that cell-extrinsic signaling molecules that modulate this balance converge on redox modulation as a critical component of their effector mechanism.