DAIDZEIN IS A MORE BIOAVAILABLE SOYMILK ISOFLAVONE THAN IS GENISTEIN IN ADULT WOMEN
DAIDZEIN IS A MORE BIOAVAILABLE SOYMILK ISOFLAVONE THAN IS GENISTEIN IN ADULT WOMEN
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DOI：
10.1093/jn/124.6.825
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发表时间：
1994-06-01
影响因子：
4.2
通讯作者：
HENDRICH, S
中科院分区：
文献类型：
--
作者：
XU, X;WANG, HJ;HENDRICH, S
大豆异黄酮被认为具有抗癌作用，但其有效剂量尚未确定。为了研究大豆异黄酮对人类的生物利用度，12 名年轻成年女性接受单剂量 0.7、1.3 和 2.0 毫克异黄酮/公斤体重的豆浆作为流质饮食的一部分。通过反相 HPLC 测定血浆、尿液和粪便中的异黄酮。在所有三种剂量中，黄豆苷元和染料木黄酮的平均 24 小时尿回收率分别约为 21% 和 9%。大豆黄酮的尿回收率显着高于金雀异黄酮（P < 0.001）。粪便中异黄酮的总排泄量仅为摄入量的1-2%。 2.0mg/kg剂量后6.5小时血浆总异黄酮浓度显着增加至4.4+/-2.5μmol/L。大豆黄酮和染料木黄酮的血浆浓度大致相等。给药后二十四小时，血浆和尿液异黄酮浓度几乎为零。尽管豆浆异黄酮似乎在肠道中被降解了 85%，但其生物利用度，尤其是大豆黄酮，可能足以发挥一些健康保护作用。
Soybean isoflavones are proposed to be anticarcinogenic, but their effective doses have not been established. To study the bioavailability of soybean isoflavones for humans, 12 young adult women received single doses of 0.7, 1.3 and 2.0 mg isoflavones/kg body wt in soybean milk as part of a liquid diet. Plasma, urine and fecal isoflavones were measured by reverse-phase HPLC. Average 24 h urinary recoveries of daidzein and genistein were approximately 21% and 9%, respectively, at all three doses. Urinary recovery of daidzein was significantly greater than that of genistein (P < 0.001). Total fecal excretion of isoflavones was only 1-2% of the ingested amount. Plasma total isoflavone concentration was significantly increased to 4.4 +/- 2.5 mu mol/L at 6.5 h after a dose of 2.0 mg/kg. The plasma concentrations of daidzein and genistein were approximately equal. Twenty-four hours after dosing, both plasma and urine isoflavone concentrations were nearly nil. Although soybean milk isoflavones seem to be 85% degraded in the intestine, the bioavailability, especially of daidzein, may be sufficient to exert some health-protective effects.