Computational particle-hemodynamics analysis and geometric reconstruction after carotid endarterectomy
Computational particle-hemodynamics analysis and geometric reconstruction after carotid endarterectomy
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DOI：
10.1016/s0010-4825(01)00007-5
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发表时间：
2001-09
影响因子：
7.7
通讯作者：
S. Hyun;C. Kleinstreuer;J. Archie
中科院分区：
文献类型：
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作者：
S. Hyun;C. Kleinstreuer;J. Archie
刚性面内颈动脉分叉处的瞬态三维层流不可压缩稀悬浮液流已通过用户增强的有限体积程序得到了解决。瞬时速度矢量和壁面剪应力矢量场说明了强烈的“扰动流”模式。讨论了血流动力学壁参数升高的表面轮廓的影响，表明这种扰动的流动和颗粒沉积位点，并显示了动脉内膜切除术颈动脉分叉和两种设计改进之间指示功能的相对比较。尽管颈动脉内膜切除术的围手术期死亡率和非致命性卒中发生率合计仅为 2% 至 7%，但最终的几何设计建议值得考虑，因为它可能显着降低术后并发症（如卒中、缺血性发作，甚至死亡）的几率。新的颈动脉分叉设计基于“扰动血流”指标功能的整体减少，包括时间平均壁剪切应力角度偏差和关键血液颗粒（例如单核细胞）的壁沉积参数。
Transient three-dimensional laminar incompressible dilute suspension flow in rigid in-plane carotid artery bifurcations has been solved with a user-enhanced finite-volume program. Instantaneous velocity vector and wall shear stress vector fields illustrate strong “disturbed flow” patterns. Implications of elevated surface contours of hemodynamic wall parameters, indicating such disturbed flows, and particle deposition sites are discussed and a relative comparison in terms of indicator functions between the endarterectomized carotid artery bifurcation and two design improvements is shown. Although the combined perioperative mortality and non-fatal stroke rate for carotid endarterectomy ranges only from 2% to 7%, the final geometric design recommendation presented merits consideration because it may significantly lower the chances of post-operative complications such as stroke, ischemic attack, or even death. The new carotid artery bifurcation design is based on the overall reduction of “disturbed flow” indicator functions, including the time-averaged wall shear stress angle deviation and a wall deposition parameter for critical blood particles, such as monocytes.