Poly(vinyl alcohol) Films Crosslinked by Glutaraldehyde Under Mild Conditions
Poly(vinyl alcohol) Films Crosslinked by Glutaraldehyde Under Mild Conditions
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DOI：
10.1002/app.29263
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发表时间：
2009-03-15
影响因子：
3
通讯作者：
Borges, Cristiano P.
中科院分区：
文献类型：
--
作者：
Figueiredo, Katia C. S.;Alves, Tito L. M.;Borges, Cristiano P.
使用温和的条件来进行生物分子在聚合物基质中的包埋是生物传感器、生物载体介导的促进传递膜和药物控释装置等广泛应用中的关键步骤。在这项研究中，我们研究了交联的聚（乙烯醇）（PVA）的戊二醛在没有酸催化剂和有机溶剂，以提高亲水性生物相容性聚合物的耐水性。选择戊二醛作为交联剂，因为它有利于与PVA的分子间反应，并且能够非特异性地结合到蛋白质上。研究了温度和戊二醛含量对PVA膜的热性能和结构性能的影响。在40 ° C下制备的膜显示出对于低戊二醛含量的最大交联密度，即在铺展溶液中为0.04重量%。较高量的交联剂导致PVA的支化。通过傅立叶变换红外分析证实，交联处理使膜的热性能提高，结晶度降低。膜的透氧率降低到Lip的2.7倍，这表明聚合物的交联成功完成。(C)2008 Wiley Periodicals，Inc.应用聚合物科学杂志111：3074-3080，2009
The use of mild conditions to perform the entrapment of biomolecules in polymeric matrices is a crucial step in a broad range of applications as biosensors, biocarrier-mediated facilitated transport membranes, and drug-controlled release devices. In this study, we investigated the crosslinking of poly(vinyl alcohol) (PVA) by glutaraldehyde in the absence of an acid catalyst and organic solvents to improve the water resistance of the hydrophilic biocompatible polymer. Glutaralclehyde was chosen as the crosslinking agent because it favors the intermolecular reaction with PVA and is able to bind nonspecifically to proteins. The effects of the temperature and glutaraldehyde content on the thermal and structural properties of the PVA films were examined. Membranes prepared at 40 degrees C showed a maximum crosslinking density for low glutaraldehyde content namely, 0.04 wt % in the spreading solution. Higher amounts of the crosslinker led to the branching of PVA. The increase in membrane thermal properties and reduction in crystallinity were ascribed to the crosslinking treatment, which was confirmed by Fourier transform infrared analysis. The oxygen permeability of the films was reduced Lip to 2.7 times, which indicated that the crosslinking of the polymer was successfully accomplished. (C) 2008 Wiley Periodicals, Inc. J Appl Polym Sci 111: 3074-3080, 2009