Short- and long-term immunogenicity and protection induced by non-replicating smallpox vaccine candidates in mice and comparison with the traditional 1st generation vaccine
Short- and long-term immunogenicity and protection induced by non-replicating smallpox vaccine candidates in mice and comparison with the traditional 1st generation vaccine
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DOI：
10.1016/j.vaccine.2007.12.059
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发表时间：
2008-03-25
期刊：
影响因子：
5.5
通讯作者：
Crance, Jean-Marc
中科院分区：
文献类型：
--
作者：
Ferrier-Rembert, Audrey;Drillien, Robert;Crance, Jean-Marc
本研究评估了三种不可复制的天花候选疫苗（改良安卡拉牛痘（MVA）、NYVAC和HR）的免疫原性和保护小鼠免受鼻内牛痘病毒攻击的能力，并将它们与传统的牛痘疫苗进行了比较。复制疫苗。非复制疫苗的单次免疫在短期内诱导了对死亡的完全保护，但在疫苗接种后150天对小鼠进行挑战时，保护与特异性中和抗体和CD4(+) t细胞反应相关，不能完全保护小鼠。初强化疫苗对接种MVA的小鼠具有长期有效的死亡保护作用，但对疾病和CD4(+) t细胞水平的保护作用在长期内低于传统疫苗。有必要对MVA进行进一步的研究，以确定最佳的免疫条件，以诱导第一代天花疫苗产生长期免疫原性和保护作用。(c) 2008 Elsevier Ltd.版权所有。
This study assessed three non-replicating smallpox vaccine candidates (modified vaccinia Ankara (MVA), NYVAC and HR) for their immunogenicity and ability to protect mice against an intranasal cowpox virus challenge and compared them with the traditional. replicating vaccine. A single immunisation with the non-replicating vaccines induced a complete protection from death at short-term, but was not fully protective when mice were challenged 150 days post-vaccination with protection correlated with the specific neutralizing antibodies and CD4(+) T-cells responses. Prime-boost vaccination enabled effective long-term protection from death for mice vaccinated with MVA, but protection from disease and CD4(+) T-cell level were lower than the ones induced by the traditional vaccine over the long-term period. Further investigations are necessary with MVA to determine the optimal conditions of immunisation to induce at long-term immunogenicity and protection observed with the 1st generation smallpox vaccine. (c) 2008 Elsevier Ltd. All rights reserved.