A Soft, High-Density Neuroelectronic Array.
A Soft, High-Density Neuroelectronic Array.
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柔软的高密度神经电子阵列。
DOI：
10.1038/s41528-023-00271-2
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发表时间：
2023
影响因子：
14.6
通讯作者：
Fang,Hui
中科院分区：
文献类型：
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作者：
Seo,KyungJin;Hill,Mackenna;Ryu,Jaehyeon;Chiang,Chia-Han;Rachinskiy,Iakov;Qiang,Yi;Jang,Dongyeol;Trumpis,Michael;Wang,Charles;Viventi,Jonathan;Fang,Hui
研究大脑活动的技术已经发生了巨大的变化，但在微创获取高通量电生理记录方面仍然存在巨大的挑战。在这里，我们开发了一个集成的神经电子阵列，是连续的，高密度和灵活的。具体而言，通过单晶体管多路复用和电流传感的设计，总共256个神经电极仅实现了2.3 × 0.3 mm2的面积，这是柔性基板上前所未有的。单晶体管多路复用采集电路进一步降低了来自电极的噪声，减少了每个像素的占用空间，并潜在地增加了器件的寿命。丝状神经电子阵列还与可滚动接触垫设计集成，允许通过注射器注射该设备，从而实现潜在的微创阵列输送。在大鼠中成功的急性听觉实验验证了阵列记录具有高音调解码准确度的神经信号的能力。总之，这些结果建立了软，高密度神经电子阵列作为有前途的设备，神经科学研究和临床应用。
Techniques to study brain activities have evolved dramatically, yet tremendous challenges remain in acquiring high-throughput electrophysiological recordings minimally invasively. Here, we develop an integrated neuroelectronic array that is filamentary, high-density and flexible. Specifically, with a design of single-transistor multiplexing and current sensing, the total 256 neuroelectrodes achieve only a 2.3 × 0.3 mm2area, unprecedentedly on a flexible substrate. A single-transistor multiplexing acquisition circuit further reduces noise from the electrodes, decreases the footprint of each pixel, and potentially increases the device’s lifetime. The filamentary neuroelectronic array also integrates with a rollable contact pad design, allowing the device to be injected through a syringe, enabling potential minimally invasive array delivery. Successful acute auditory experiments in rats validate the ability of the array to record neural signals with high tone decoding accuracy. Together, these results establish soft, high-density neuroelectronic arrays as promising devices for neuroscience research and clinical applications.