The First Synthesis of a Novel 5:7:5-Fused Diimidazodiazepine Ring System and Some of Its Chemical Properties
The First Synthesis of a Novel 5:7:5-Fused Diimidazodiazepine Ring System and Some of Its Chemical Properties
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DOI：
10.1021/ol8020176
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发表时间：
2008-10-16
期刊：
影响因子：
5.2
通讯作者：
Hosmane, Ramachandra S.
中科院分区：
文献类型：
--
作者：
Kumar, Raj;Ujjinamatada, Ravi K.;Hosmane, Ramachandra S.
首次报道了一种新型的5：7：5稠合杂环体系--双咪唑二氮杂环化合物的合成。探讨了环系在中性碳和氮亲核试剂催化下容易发生的亲核加成反应的倾向。该环系统在DNA链间交联链的形成和修复的机理研究中具有潜在的应用前景。
The first synthesis of a novel 5:7:5-fused heterocyclic ring system, a diimidazodiazepine, is reported. The propensity of the ring system to undergo facile, acid-catalyzed nucleophilic addition reactions by neutral carbon and nitrogen nucleophiles has been explored. The ring system has potential future applications in mechanistic studies of formation and repair of DNA interstrand cross-links.