Extracellular matrix-integrin interactions in osteoblast function and tissue remodeling
Extracellular matrix-integrin interactions in osteoblast function and tissue remodeling
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DOI：
10.1016/s8756-3282(99)00106-4
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发表时间：
1999-07-01
期刊：
影响因子：
4.1
通讯作者：
Damsky, CH
中科院分区：
文献类型：
--
作者：
Damsky, CH
以前的工作与培养的原代细胞，从我们的小组和其他实验室，已经表明，来自细胞外基质的信号，由整合素转导，在调节基因表达，组织特异性分化，和原代成骨细胞和成纤维细胞的生存发挥关键作用。本摘要将集中在我们最近的工作，处理细胞-细胞外基质相互作用和粘着斑激酶在调节成骨细胞和成纤维细胞中的细胞存活中的作用，以及β 1整合素在骨组织组织和骨重塑中的作用。(C)1999年，Elsevier Science Inc. All rights reserved.
Previous work with cultured primary cells, from our group and from other laboratories, has shown that signals from extracellular matrix, transduced by integrins, play critical roles in regulating gene expression, tissue-specific differentiation, and survival of primary osteoblasts and fibroblasts. This summary will focus on our most recent work, dealing with the role of cell-extracellular matrix interactions and focal adhesion kinase in regulating cell survival in osteoblasts and fibroblasts, and the role of beta 1 integrins in tissue organization and remodeling in bone. (C) 1999 by Elsevier Science Inc. All rights reserved.