Mapping Human Genetic Diversity in Asia
Mapping Human Genetic Diversity in Asia
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DOI：
10.1126/science.1177074
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发表时间：
2009-12-11
期刊：
影响因子：
56.9
通讯作者：
Zilfalil, Bin Alwi
中科院分区：
文献类型：
--
作者：
Abdulla, Mahmood Ameen;Ahmed, Ikhlak;Zilfalil, Bin Alwi
亚洲拥有实质性的文化和语言多样性，但是整个大陆的遗传变异的地理结构仍然是神秘的。在这里，我们报告了对亚洲人口广泛地理样本的常染色体变异的大规模调查。我们的结果表明，遗传血统与语言隶属关系和地理密切相关。尽管人群之间流动普遍，但大多数人群都表现出种族/语言群体中的相关性。在东南亚（海洋）或中南亚洲（CSA）种群中，可以找到超过90％的东亚（EA）单倍型，并显示出较短的结构，而单倍型的多样性从南到北部降低。此外，仅在海中发现了50％的EA单倍型，仅在CSA中发现了5％，这表明海是EA人群的主要地理来源。
Asia harbors substantial cultural and linguistic diversity, but the geographic structure of genetic variation across the continent remains enigmatic. Here we report a large-scale survey of autosomal variation from a broad geographic sample of Asian human populations. Our results show that genetic ancestry is strongly correlated with linguistic affiliations as well as geography. Most populations show relatedness within ethnic/linguistic groups, despite prevalent gene flow among populations. More than 90% of East Asian (EA) haplotypes could be found in either Southeast Asian (SEA) or Central-South Asian (CSA) populations and show clinal structure with haplotype diversity decreasing from south to north. Furthermore, 50% of EA haplotypes were found in SEA only and 5% were found in CSA only, indicating that SEA was a major geographic source of EA populations.