In vivo porcine intradiscal pressure as a function of external loading
In vivo porcine intradiscal pressure as a function of external loading
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DOI：
10.1097/01.bsd.0000092068.78152.00
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发表时间：
2004-08-01
影响因子：
--
通讯作者：
Hansson, T
中科院分区：
文献类型：
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作者：
Ekström, L;Holm, S;Hansson, T
背景：日常活动期间的脊柱负荷与椎间盘维持其完整性的能力有关，一直是脊柱研究的一个主要问题。本研究的目的是在猪体内模型中建立髓核中的椎间盘压力与施加到运动节段的负载之间的关系。方法：本研究使用了九头家猪。通过四个椎弓根内螺钉将微型伺服液压测试机固定在腰椎上，螺钉从两侧插入 L2 和 L3 椎骨。将压力针穿过 L2-L3 椎间盘环的外侧部分插入髓核。在加载方案期间收集力、变形和椎间盘内压力数据，该加载方案包括按递增顺序施加一组恒定载荷，即 50、100、150、200 和 250 N。每个载荷施加 30 秒，然后恢复 30 秒。结果：发现在所有情况下，椎间盘内核压力与所施加的载荷相关。线性回归分析得出以下方程：椎间盘内压力 (MPa) = 0.08 + 1.25E(-3)（负荷，N），r(2) = 0.81，n = S。椎间盘内压力也与应力高度线性相关。发现椎间盘内在压力为 81 +/- 5 kPa。结果还表明，椎间盘内的压力表现出蠕变行为。结论：总而言之，椎间盘髓核内的压力与所施加的载荷和应力呈线性相关。
Background: Spinal loading during daily activity as it relates to the ability of the intervertebral disc to sustain its integrity has been a major issue in spinal research. The purpose of this investigation was to establish the relationship between the intervertebral disc pressure in the nucleus and the load applied to the motion segment in an in vivo porcine model.Methods: Nine domestic pigs were used in this study. A miniaturized servohydraulic testing machine was affixed to the lumbar spine via four intrapedicular screws, which were inserted bilaterally into the L2 and L3 vertebrae. A pressure needle was inserted through the lateral part of the L2-L3 disc annulus and into the nucleus pulposus. Force, deformation, and intradiscal pressure data were collected during a loading scheme that consisted of applying a set of constant loads in increasing order, that is, 50, 100, 150, 200, and 250 N. Each load was applied for 30 seconds followed by 30-second restitution.Results: Intradiscal nucleus pressure was found to Correlate to the applied load in all cases. Linear regression analyses resulted in the following equation: intradiscal pressure (MPa) = 0.08 + 1.25E(-3) (load, N), r(2) = 0.81, n = S. Intradiscal pressure was also highly linearly dependent on the stress. The intrinsic intradiscal pressure was found to be 81 +/- 5 kPa. The results also indicated that the pressure within the disc exhibited a creep behavior.Conclusion: in conclusion, pressure in the nucleus of the porc me intervertebral disc was linearly related to the applied load and stress.