Mitochondrial thioredoxin reductase 2 is elevated in long-lived primate as well as rodent species and extends fly mean lifespan.
Mitochondrial thioredoxin reductase 2 is elevated in long-lived primate as well as rodent species and extends fly mean lifespan.
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DOI：
10.1111/acel.12596
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发表时间：
2017-08
期刊：
影响因子：
7.8
通讯作者：
Miller RA
中科院分区：
文献类型：
--
作者：
Pickering AM;Lehr M;Gendron CM;Pletcher SD;Miller RA
In a survey of enzymes related to protein oxidation and cellular redox state, we found activity of the redox enzyme thioredoxin reductase (TXNRD) to be elevated in cells from long‐lived species of rodents, primates, and birds. Elevated TXNRD activity in long‐lived species reflected increases in the mitochondrial form, TXNRD2, rather than the cytosolic forms TXNRD1 and TXNRD3. Analysis of published RNA‐Seq data showed elevated TXNRD2 mRNA in multiple organs of longer‐lived primates, suggesting that the phenomenon is not limited to skin‐derived fibroblasts. Elevation of TXNRD2 activity and protein levels was also noted in liver of three different long‐lived mutant mice, and in normal male mice treated with a drug that extends lifespan in males. Overexpression of mitochondrial TXNRD2 in Drosophila melanogaster extended median (but not maximum) lifespan in female flies with a small lifespan extension in males; in contrast, overexpression of the cytosolic form, TXNRD1, did not produce a lifespan extension.
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影响因子：
7.8
作者：
Harrison DE;Strong R;Allison DB;Ames BN;Astle CM;Atamna H;Fernandez E;Flurkey K;Javors MA;Nadon NL;Nelson JF;Pletcher S;Simpkins JW;Smith D;Wilkinson JE;Miller RA
通讯作者：
Miller RA
影响因子：
14.9
作者：
Peng X;Thierry-Mieg J;Thierry-Mieg D;Nishida A;Pipes L;Bozinoski M;Thomas MJ;Kelly S;Weiss JM;Raveendran M;Muzny D;Gibbs RA;Rogers J;Schroth GP;Katze MG;Mason CE
通讯作者：
Mason CE
影响因子：
4.8
作者：
Al-Regaiey, KA;Masternak, MM;Bartke, A
通讯作者：
Bartke, A
影响因子：
2.8
作者：
Harper, James M.;Wang, Min;Miller, Richard A.
通讯作者：
Miller, Richard A.
DOI：
10.1073/pnas.111158898
发表时间：
2001-06-05
影响因子：
11.1
作者：
Flurkey, K;Papaconstantinou, J;Harrison, DE
通讯作者：
Harrison, DE