Screening for Autism Spectrum Disorders with the Brief Infant-Toddler Social and Emotional Assessment
Screening for Autism Spectrum Disorders with the Brief Infant-Toddler Social and Emotional Assessment
复制标题
DOI：
10.1371/journal.pone.0097630
复制
发表时间：
2014-05-22
期刊：
影响因子：
3.7
通讯作者：
Raat, Hein
中科院分区：
文献类型：
--
作者：
Kruizinga, Ingrid;Visser, Janne C.;Raat, Hein
目的：在儿童（预防性）保健中使用家长填写的问卷有助于早期发现心理社会问题和精神病理，包括自闭症谱系障碍（ASD）。一个很有前途的调查问卷是婴儿-幼儿社会和情感评估（BITSEA）。评估BITSEA问题和能力量表以及新计算的自闭症评分对ASD的筛查准确性。方法：数据收集于2010年4月至2011年4月，来自社区样本的2岁儿童（N = 3127），与诊断为ASD的学龄前儿童样本（N = 159）相结合。对总体人群和按儿童性别划分的亚组进行受试者工作特征（ROC）曲线下面积检查，并在BITSEA问题、能力和自闭症评分范围内报告敏感性、特异性、阳性和阴性似然比、诊断优势比和约登指数。结果：问题量表的ROC曲线下面积为0.90(0.87 ~ 0.92)，能力量表的ROC曲线下面积为0.93(0.91 ~ 0.95)，自闭症评分的ROC曲线下面积为0.95（0.93 ~ 0.97）。与问题量表相比，对于总体人群而言，自闭症评分的筛查准确性明显更好。能力量表对女孩的筛查准确率（AUC = 0.97; 95%CI = 0.95 ~ 0.98）显著高于男孩（AUC = 0.91; 95%CI = 0.88 ~ 0.94）。结论：BITSEA量表和新计算的自闭症评分对自闭症患儿有较好的鉴别能力。因此，BITSEA可能有助于ASD的早期发现，从而对儿童的发展产生有益的影响。
Objective: Using parent-completed questionnaires in (preventive) child health care can facilitate the early detection of psychosocial problems and psychopathology, including autism spectrum disorders (ASD). A promising questionnaire for this purpose is the Brief Infant-Toddler Social and Emotional Assessment (BITSEA). The screening accuracy with regard to ASD of the BITSEA Problem and Competence scales and a newly calculated Autism score were evaluated.Method: Data, that was collected between April 2010 and April 2011, from a community sample of 2-year-olds (N = 3127), was combined with a sample of preschool children diagnosed with ASD (N = 159). For the total population and for subgroups by child's gender, area under the Receiver Operating Characteristic (ROC) curve was examined, and across a range of BITSEA Problem, Competence and Autism scores, sensitivity, specificity, positive and negative likelihood ratio's, diagnostic odds ratio and Youden's index were reported.Results: The area under the ROC curve (95% confidence interval, [95%CI]) of the Problem scale was 0.90(0.87-0.92), of the Competence scale 0.93(0.91-0.95), and of the Autism score 0.95(0.93-0.97). For the total population, the screening accuracy of the Autism score was significantly better, compared to the Problem scale. The screening accuracy of the Competence scale was significantly better for girls (AUC = 0.97; 95%CI = 0.95-0.98) than for boys (AUC = 0.91; 95%CI = 0.88-0.94).Conclusion: The results indicate that the BITSEA scales and newly calculated Autism score have good discriminative power to differentiate children with and without ASD. Therefore, the BITSEA may be helpful in the early detection of ASD, which could have beneficial effects on the child's development.