IMMUNE-RESPONSE TO INFLUENZA VACCINATION OF ELDERLY PEOPLE - A RANDOMIZED DOUBLE-BLIND PLACEBO-CONTROLLED TRIAL
IMMUNE-RESPONSE TO INFLUENZA VACCINATION OF ELDERLY PEOPLE - A RANDOMIZED DOUBLE-BLIND PLACEBO-CONTROLLED TRIAL
复制标题
DOI：
10.1016/0264-410x(94)90241-0
复制
发表时间：
1994-10-01
期刊：
影响因子：
5.5
通讯作者：
KNOTTNERUS, JA
中科院分区：
文献类型：
--
作者：
GOVAERT, TME;SPRENGER, MJW;KNOTTNERUS, JA
本研究的目的是通过一项随机、双盲、安慰剂对照试验，确定老年人对流感疫苗接种的免疫应答。在注射流感疫苗或安慰剂之前，从1838名60岁及以上的人身上采集静脉血。三周后采集了第二份血样。通过比较几何平均滴度和接种前后以及每种毒株所有血清中具有保护性抗体滴度的受试者百分比，测量抗体反应bq。根据所研究的菌株，在43-68%接种疫苗的人中发现了保护性抗体滴度。有潜在风险的患者表现出与其他参与者相似的反应。我们的结论是，流感疫苗接种在老年人提供了一个合理的良好的免疫反应。需要研究良好的免疫反应是否会降低流感的发病率。
The objective of this study was to determine the immune response to influenza vaccination in elderly people, using a randomized, double-blind, placebo-controlled trial. Venous blood was taken from 1838 people aged 60 years and older, prior to injection with the influenza vaccine or a placebo. A second blood sample was taken three weeks later. The antibody reaction was measured bq, comparing the geometric mean titre and the percentage of participants who had a protective antibody titre before and after vaccination and for all sera of each strain. A protective antibody titre was found in 43-68% of those who had received the vaccine, depending on the strain investigated. Patients potentially at risk showed a response similar to the other participants. We conclude that influenza vaccination in elderly people provides a reasonable to good immune response. Research is needed on whether a good immune response decreases the incidence of influenza.