Early-life rotavirus and norovirus infections in relation to development of atopic manifestation in infants
Early-life rotavirus and norovirus infections in relation to development of atopic manifestation in infants
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DOI：
10.1111/j.1365-2222.2008.03128.x
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发表时间：
2009-02-01
影响因子：
6.1
通讯作者：
Koopmans, M.
中科院分区：
文献类型：
--
作者：
Reimerink, J.;Stelmawz, F.;Koopmans, M.
过去几十年来，发达国家特应性疾病（ad）发病率的增加与儿童感染暴露的减少有关。目的探讨早期肠道病毒感染与1 ~ 2岁儿童特应性症状（湿疹、喘息、特应性致敏）发生的关系。方法在考拉出生队列研究中，我们评估了1岁时轮状病毒和诺如病毒（GGI.1和ggi .4）血清IgG阳性。这与1岁和2岁时的过敏致敏[特异性免疫球蛋白E (IgE)]有关，并且父母在前2年报告了湿疹和喘息，采用了调整混杂因素的logistic回归分析。结果轮状病毒血清阳性（39%）与1岁和2岁复发性喘息的意外较高风险相关[调整比值比（OR） 3.1, 95%可信区间（CI） 1.1-9.1]，以及持续和新复发性喘息（调整比值比（OR） 2.7, 95%可信区间1.1-6.2）。未发现肠道病毒血清阳性与特应性表现之间的进一步关联。结论：我们的数据没有显示肠道病毒感染对幼儿对过敏原的IgE反应有明显的保护作用，但第一年轮状病毒感染是发生喘息的危险因素。然而，为了确定肠道病毒感染的真正重要性，特别是在阿尔茨海默病病因学中的累积效应，这需要对老年人进行随访。暴露于轮状病毒可能提供了一个新的和有趣的焦点婴儿喘息和后来的哮喘发展。
Background The increase in incidence of atopic diseases (ADs) in the developed world over the past decades has been associated with reduced exposure of childhood infections.Objective To investigate the relation between early intestinal viral infections in relation to the development of atopic symptoms (eczema, wheeze and atopic sensitization) in the first and second year(s) of life.Methods In the KOALA Birth Cohort Study, we assessed IgG seropositivity for rota- and norovirus (GGI.1 and GGII.4) at 1 year of age. This was related to allergic sensitization [specific immunoglobulin E (IgE)] at 1 and 2 years, and parent reported eczema and wheeze in the first 2 years, using logistic regression analysis adjusted for confounders.Results Rotavirus seropositivity (39%) was associated with an unexpected higher risk of recurrent wheeze in the first and second year of life [adjusted odds ratio (OR) 3.1 and 95% confidence intervals (CI) 1.1-9.1] and persistent and new recurrent wheeze (adjusted OR 2.7 and 95% CI 1.1-6.2). No further associations were found between intestinal viral seropositivity and atopic manifestations.Conclusion Our data did not show a clear protection by enteric viral infections in young children on development of IgE response to allergens, but rotavirus infection in the first year was a risk factor for wheeze. However, this needs to be followed up to older ages in order to establish the true importance of intestinal viral infections and especially cumulative effects in AD aetiology. Exposure to rotavirus may offer a new and interesting focus on infant wheeze and later asthma development.