Long-term effects of differential early rearing in rhesus macaques: behavioral reactivity in adulthood.
Long-term effects of differential early rearing in rhesus macaques: behavioral reactivity in adulthood.
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DOI：
10.1002/dev.20613
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发表时间：
2012-07
影响因子：
2.2
通讯作者：
Bennett AJ
中科院分区：
文献类型：
--
作者：
Corcoran CA;Pierre PJ;Haddad T;Bice C;Suomi SJ;Grant KA;Friedman DP;Bennett AJ
不良的早期经历与人类的一系列有害健康结果有关，包括情感障碍的高风险。使用非人灵长类动物早期逆境模型的长期模型的研究表明，托儿所饲养的猴子在生物行为发育的多个方面表现出改变;然而，很少有研究评估社会情感行为变化在成年期的持续性。我们评估了早期饲养经验对成年动物对焦虑样行为的有效评估的影响，人类入侵者范式（HIP）。我们测试了22只恒河猴，它们要么是托儿所饲养的（NR），要么是与母亲一起饲养的（母亲饲养的; MR）。与MR猴相比，NR猴的行为受到抑制，运动和探索行为减少。NR动物的冻结率略有增加。总之，这些研究结果表明，不同的婴儿养育经验对社会情感行为的影响持续到成年，有证据表明NR猴的抑制作用更大。
Adverse early experiences are associated with a range of deleterious health outcomes in humans, including higher risk for affective disorders. Studies using a long-standing model of nonhuman primate model of early adversity have demonstrated that nursery-reared monkeys exhibit alterations in multiple aspects of biobehavioral development; however, few studies have evaluated the persistence of socioaffective behavioral changes through adulthood. We evaluated the effects of early rearing experience on adult animals’ response to a well-validated assessment of anxiety-like behavior, the Human Intruder Paradigm (HIP). We tested twenty-two rhesus monkeys who were either nursery-reared (NR) or reared with their mothers (mother-reared; MR). NR monkeys were inhibited in their behavior compared to MR monkeys, with reduced locomotion and exploratory behaviors. NR animals showed a marginal increase in freezing. Together these findings demonstrate that the consequences of differential infant rearing experience on socioaffective behavior persist into adulthood, with evidence of greater inhibition in NR monkeys.