EFFECTS OF CYCLOSPORINE IMMUNOSUPPRESSION IN INSULIN-DEPENDENT DIABETES-MELLITUS OF RECENT ONSET
EFFECTS OF CYCLOSPORINE IMMUNOSUPPRESSION IN INSULIN-DEPENDENT DIABETES-MELLITUS OF RECENT ONSET
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DOI：
10.1126/science.6367043
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发表时间：
1984-01-01
期刊：
影响因子：
56.9
通讯作者：
WOLFE, BMJ
中科院分区：
文献类型：
--
作者：
STILLER, CR;DUPRE, J;WOLFE, BMJ
I型糖尿病可能是一种自身免疫性疾病，尽管证据主要是间接的。确诊后的疾病自然病史包括大多数患者的部分缓解，但只有大约3%的患者实现了短暂的胰岛素独立。β细胞功能，如血浆C肽浓度所示，在6至30个月内丧失，胰岛细胞抗体在1至2年内消失。本文介绍了一项先导性研究，其中41例患者接受了免疫抑制剂环孢素2-12个月的治疗。在确诊后6周内接受治疗的30例患者中，16例在血浆C-肽浓度正常和胰岛细胞抗体滴度下降的情况下实现了胰岛素非依赖性。在确诊后8至44周进入研究的11名患者中，有两人达到了这种状态。这些结果表明，应该对环孢素治疗I型糖尿病的效果进行对照试验。
Type I diabetes may be an autoimmune disorder, although the evidence is largely circumstantial. The natural history of the disease after diagnosis includes partial remission in most patients, but only about 3 percent achieve transient insulin independence. β Cell function, as indicated by the plasma concentration of C-peptide, is lost over 6 to 30 months and islet cell antibodies disappeared over 1 to 2 years. This article describes a pilot study in which 41 patients were treated with the immunosuppressive agent cyclosporine for 2 to 12 months. Of 30 patients treated within 6 weeks of diagnosis, 16 became insulin independent with concentrations of plasma C-peptide in the normal range and decreasing titers of islet cell antibodies. Of 11 patients who entered the study 8 to 44 weeks after diagnosis, two achieved this state. These results indicate that a controlled trial of the effects of cyclosporine in type I diabetes should be conducted.