In a swine model, chest compressions cause ventricular capture and, by means of a long-short sequence, ventricular fibrillation.
In a swine model, chest compressions cause ventricular capture and, by means of a long-short sequence, ventricular fibrillation.
复制标题
在猪模型中，胸部压缩会导致心室捕获，并通过长短序列（室纤颤）。
DOI：
10.1161/circep.108.767855
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发表时间：
2008-10
期刊：
影响因子：
--
通讯作者：
Ideker RE
中科院分区：
文献类型：
--
作者：
Osorio J;Dosdall DJ;Robichaux RP Jr;Tabereaux PB;Ideker RE
During resuscitation, fibrillation often recurs. In swine, we studied refibrillation after long duration ventricular fibrillation (LDVF) investigating an association with chest compressions (CCs). In Protocol A, 47 episodes of LDVF lasting at least 2.5 min were induced in 8 animals. Following defibrillation, CCs were required for 35 episodes and delivered with a pneumatic device (Lucas-CPR). In 9 episodes, refibrillation occurred within 2 s of CC initiation (Group 1) and in 26 episodes CCs were delivered without refibrillation (Group 2). From the ECG and intracardiac electrodes, the RR interval preceding CCs, the shortest cycle length during the first 2 CCs (Short) and the preceding cycle length (Long) were measured. A similar study was conducted in 3 more animals without intracardiac catheters (Protocol B). In Protocol A, the mean RR before CC was 665±292ms in Group 1 and 769±316 in Group 2. CCs stimulated ventricular beats in all 35 episodes. The Short and Long intervals were shorter in Group 1 (215±31ms and 552±210ms), than in Group 2 (402±153ms and 699±147ms) (p=0.009 and p=0.04, respectively). The Prematurity Index (Short/RR) was lower in Group 1 (0.35±0.09) than Group 2 (0.58±0.21) (p<0.01). A Short interval < 231 ms predicted refibrillation with 88% sensitivity and 91% specificity. In Protocol B, CCs were required in 11 episodes, causing ventricular stimulation in all of them and VF within the first 2 CCs in 3. Under some conditions, CC during resuscitation can stimulate the ventricles and initiate VF by a long-short sequence.
