MCP1 SNPs and pulmonary tuberculosis in cohorts from West Africa, the USA and Argentina: lack of association or epistasis with IL12B polymorphisms.
MCP1 SNPs and pulmonary tuberculosis in cohorts from West Africa, the USA and Argentina: lack of association or epistasis with IL12B polymorphisms.
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DOI：
10.1371/journal.pone.0032275
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Sirugo G
中科院分区：
文献类型：
--
作者：
Velez Edwards DR;Tacconelli A;Wejse C;Hill PC;Morris GA;Edwards TL;Gilbert JR;Myers JL;Park YS;Stryjewski ME;Abbate E;Estevan R;Rabna P;Novelli G;Hamilton CD;Adegbola R;Østergaar L;Williams SM;Scott WK;Sirugo G
单核细胞趋化蛋白-1 （MCP-1）是一种趋化因子，在单核细胞募集到结核分枝杆菌感染部位中起重要作用，先前的研究报道MCP1的遗传变异与肺结核（PTB）的易感性差异有关。我们在多种族病例对照设计中检测了8个MCP1单核苷酸多态性（snp），其中包括：来自几内亚比绍的321例病例和346例对照，来自冈比亚的258例病例和271例对照，来自美国（非裔美国人）的295例病例和179例对照，以及来自美国和阿根廷的欧洲血统的237例病例和144例对照。两个位点的相互作用也检测了MCP1和白细胞介素12B （IL12B）的多态性，IL12B是另一个与PTB风险有关的基因。对先前相关的MCP1 snp rs1024611（−2581A/G）、rs2857656（−362G/C）和rs4586 （+900C/T）的检测没有显示出关联的证据。rs2857656与IL12B SNP rs2288831在非洲人中存在交互作用，但在几内亚人和冈比亚人中则相反（OR = 1.90, p = 0.001）。我们的数据表明，MCP1基因变异的影响并不明确，需要进一步的研究来阐明其在结核病易感性中的作用。
The monocyte chemotactic protein-1 (MCP-1) is a chemokine that plays an important role in the recruitment of monocytes to M. tuberculosis infection sites, and previous studies have reported that genetic variants in MCP1 are associated with differential susceptibility to pulmonary tuberculosis (PTB). We examined eight MCP1 single nucleotide polymorphisms (SNPs) in a multi-ethnic, case-control design that included: 321 cases and 346 controls from Guinea-Bissau, 258 cases and 271 controls from The Gambia, 295 cases and 179 controls from the U.S. (African-Americans), and an additional set of 237 cases and 144 controls of European ancestry from the U.S. and Argentina. Two locus interactions were also examined for polymorphisms in MCP1 and interleukin 12B (IL12B), another gene implicated in PTB risk. Examination of previously associated MCP1 SNPs rs1024611 (−2581A/G), rs2857656 (−362G/C) and rs4586 (+900C/T) did not show evidence for association. One interaction between rs2857656 and IL12B SNP rs2288831 was observed among Africans but the effect was in the opposite direction in Guineans (OR = 1.90, p = 0.001) and Gambians (OR = 0.64, p = 0.024). Our data indicate that the effect of genetic variation within MCP1 is not clear cut and additional studies will be needed to elucidate its role in TB susceptibility.
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DOI：
10.1084/jem.20050126
发表时间：
2005-12-19
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Flores-Villanueva PO;Ruiz-Morales JA;Song CH;Flores LM;Jo EK;Montaño M;Barnes PF;Selman M;Granados J
通讯作者：
Granados J
影响因子：
3.7
作者：
Ganachari, Malathesha;Ruiz-Morales, Jorge A.;Flores-Villanueva, Pedro O.
通讯作者：
Flores-Villanueva, Pedro O.
DOI：
10.1098/rstb.1997.0118
发表时间：
1997-09-29
影响因子：
6.3
作者：
Blackwell, JM;Black, GF;Shaw, MA
通讯作者：
Shaw, MA
CCL2对结核分枝杆菌的反应与结核病中的疾病严重程度有关。
影响因子：
3.7
作者：
Hasan Z;Cliff JM;Dockrell HM;Jamil B;Irfan M;Ashraf M;Hussain R
通讯作者：
Hussain R
影响因子：
56.9
作者：
Gabriel, SB;Schaffner, SF;Altshuler, D
通讯作者：
Altshuler, D