PTEN expression in renal cell carcinoma and oncocytoma and prognosis
PTEN expression in renal cell carcinoma and oncocytoma and prognosis
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DOI：
10.1080/00313020701570012
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发表时间：
2007-01-01
期刊：
影响因子：
4.5
通讯作者：
Moser, Patrizia L.
中科院分区：
文献类型：
--
作者：
Hager, Martina;Haufe, Heike;Moser, Patrizia L.
目的：肿瘤抑制基因PTEN(10号染色体缺失的磷酸酶和张力蛋白同源物)的缺失或失活与多种人类癌症的发生有关。方法：用抗PTEN抗体孵育493例肾细胞癌、21例嗜酸细胞瘤和461例非肿瘤肾组织的组织芯片，分析PTEN的表达。结果：肾细胞癌，尤其是嗜酸细胞瘤，PTEN主要在胞浆表达。与嗜酸细胞瘤相比，PTEN在肾癌亚型中的表达明显降低。PTEN在肉瘤样肾细胞癌中的表达与非肉瘤样肾细胞癌相当。结论：肾肿瘤(肾细胞癌和嗜酸细胞瘤)PTEN蛋白主要表达于胞浆。PTEN表达的减少似乎是肾细胞癌发生的早期步骤。然而，肾细胞癌中PTEN的表达模式显然不能预测患者的生存。
Aims: Deletion or inactivation of the tumour suppressor gene PTEN (phosphatase and tensin homologue deleted from chromosome 10) contributes to tumorigenesis in a variety of human carcinomas. The present study evaluated PTEN expression in renal cell carcinomas and oncocytomas.Methods: A tissue microarray from 493 specimens including renal cell carcinomas (n=440), oncocytomas (n=21) and tumour-negative renal tissue (n=32) from patients (n=461) was incubated with an anti-PTEN antibody for subsequent analysis of PTEN expression. Furthermore, the effect of PTEN expression on the survival of renal carcinoma patients was evaluated.Results: Renal cell carcinomas, and even more pronouncedly oncocytomas, expressed PTEN predominantly in the cytoplasm. In contrast to oncocytomas, PTEN expression was typically decreased in renal cell carcinoma subtypes. PTEN expression in sarcomatoid renal cell carcinomas was comparable to that in non-sarcomatoid subtypes. The PTEN expression pattern had no significant influence on prognosis.Conclusions: Renal tumours (renal cell carcinomas and oncocytomas) express PTEN protein predominantly in the cytoplasm. A reduction in PTEN expression appears to be an early step in renal cell carcinogenesis. However, the PTEN expression pattern of renal cell carcinomas apparently is not prognostic for patient survival.