The flavonoid monoHER prevents monocrotaline-induced hepatic sinusoidal injury in rats
The flavonoid monoHER prevents monocrotaline-induced hepatic sinusoidal injury in rats
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DOI：
10.1002/jso.23046
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发表时间：
2012-07-01
影响因子：
2.5
通讯作者：
Damink, Steven W. M. Olde
中科院分区：
文献类型：
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作者：
Ezzat, Tarek;van den Broek, Maartje A. J.;Damink, Steven W. M. Olde
背景：50-70%的肝结直肠转移患者在奥沙利铂治疗后发生窦道阻塞综合征（SOS）。SOS与门静脉高压症有关，由内皮细胞氧化损伤和基质金属蛋白酶（MMP）诱导引起。我们研究了一种黄酮类化合物（monoHER）对SOS的预防作用。方法建立大鼠单胆碱（MTC） SOS模型，经单胆碱预处理。我们研究了肝细胞损伤和MMP的表达。在结直肠癌细胞系中，研究了单克隆her对奥沙利铂细胞毒性的潜在抑制作用。结果MonoHER改善了MCT后门静脉压力升高(72？Hr: 7.3±2.7？mmHg vs 11.4 +/- 3.0？mmHg, P = 0.016monoHER诉MCT， P？
Background Sinusoidal obstruction syndrome (SOS) occurs in 50-70% of patients after oxaliplatin treatment for hepatic colorectal metastasis. SOS is associated with portal hypertension and is caused by oxidative damage to endothelial cells and matrix metalloproteinase (MMP) induction. We studied the effect of a flavonoid (monoHER) on SOS prevention. Methods A monocrotaline (MTC) SOS model was used in rats, with pre-treatment of monoHER. We studied hepatocellular damage and MMP expression. The potential inhibition of oxaliplatin cytotoxicity by monoHER was tested in vitro in colorectal cancer cell lines. Results MonoHER ameliorated the increase in portal pressure after MCT (72?hr: 7.3 +/- 2.7?mmHg vs. 11.4 +/- 3.0?mmHg, P?=?0.016 MCT?+?monoHER vs. MCT, P?