Basic MR relaxation mechanisms and contrast agent design.
Basic MR relaxation mechanisms and contrast agent design.
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基本的MR松弛机制和对比剂设计。
DOI：
10.1002/jmri.24787
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发表时间：
2015-09
期刊：
影响因子：
--
通讯作者：
Sherry AD
中科院分区：
文献类型：
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作者：
De León-Rodríguez LM;Martins AF;Pinho MC;Rofsky NM;Sherry AD
由于硬件和软件的创新以及外源性造影剂的开发和应用，磁共振成像（MRI）的诊断能力经历了持续和实质性的发展。自第一种MRI造影剂被批准用于临床使用以来的30年里，对MR造影剂的依赖在很大程度上持续存在，以提高图像质量和更高的对比度分辨率，并提供正常和异常组织的额外功能表征。MR造影剂的进一步发展是寻求持续增强诊断能力的重要组成部分。在这篇综述中，我们将详细介绍在设计和使用MR造影剂时的许多重要考虑因素。我们将提供一个角度的化学稳定性的重要性，特别是动力学稳定性，以及这如何影响人们对金属配体造影剂的安全性的思考。我们将在探针设计策略的背景下讨论磁共振弛豫所涉及的机制。对目前可用的造影剂的简要描述将伴随着深入的讨论，强调有前途的MRI造影剂在未来的临床和研究应用的发展。我们的目的是让不同的受众更好地了解开发新型安全高效MR造影剂所涉及的因素，同时，让人们了解新型反应剂可以提供的生理学和疾病见解。
The diagnostic capabilities of magnetic resonance imaging (MRI) have undergone continuous and substantial evolution by virtue of hardware and software innovations and the development and implementation of exogenous contrast media. Thirty years since the first MRI contrast agent was approved for clinical use, a reliance on MR contrast media persists largely to improve image quality with higher contrast resolution and to provide additional functional characterization of normal and abnormal tissues. Further development of MR contrast media is an important component in the quest for continued augmentation of diagnostic capabilities. In this review we will detail the many important considerations when pursuing the design and use of MR contrast media. We will offer a perspective on the importance of chemical stability, particularly kinetic stability, and how this influences one's thinking about the safety of metal-ligand based contrast agents. We will discuss the mechanisms involved in magnetic resonance relaxation in the context of probe design strategies. A brief description of currently available contrast agents will be accompanied by an in-depth discussion that highlights promising MRI contrast agents in development for future clinical and research applications. Our intention is to give a diverse audience an improved understanding of the factors involved in developing new types of safe and highly efficient MR contrast agents and, at the same time, provide an appreciation of the insights into physiology and disease that newer types of responsive agents can provide.