Cytomorphology of notochordal and chondrocytic cells from the nucleus pulposus: a species comparison
Cytomorphology of notochordal and chondrocytic cells from the nucleus pulposus: a species comparison
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DOI：
10.1111/j.0021-8782.2004.00352.x
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发表时间：
2004-11-01
影响因子：
2.4
通讯作者：
Duncan, NA
中科院分区：
文献类型：
--
作者：
Hunter, CJ;Matyas, JR;Duncan, NA
椎间盘（IVD）的髓核包含处于不同成熟阶段的多种细胞类型。这种组织由胚胎脊索细胞形成，或在其帮助下形成，在发育过程中，这些细胞似乎被一群来源不明的类软骨细胞所取代。然而，这种转变发生的时间差异很大，取决于所研究动物的种类——甚至品种。脊柱研究人员对于这些残留的脊索细胞的存在是否对椎间盘退变模型有重大影响，以及因此哪种模型最能代表人类状况存在相当大的争议。本研究对腰椎研究中常用的几种不同物种进行了研究，以探索椎间盘内脊索细胞的变异性。
The nuclei pulposi of the intervertebral discs (IVDs) contain a mixed population of cell types at various stages of maturation. This tissue is formed either by or with the help of cells from the embryonic notochord, which appear to be replaced during development by a population of chondrocyte-like cells of uncertain origin. However, this transition occurs at widely varying times, depending upon the species - or even breed - of the animal being examined. There is considerable debate among spine researchers as to whether the presence of these residual notochordal cells has a significant impact upon IVD degeneration models, and thus which models may best represent the human condition. The present study examines several different species commonly used in lumbar spine investigations to explore the variability of notochordal cells in the IVD.