High-Dose Treatment With Telmisartan Induces Monocytic Peroxisome Proliferator-Activated Receptor-γ Target Genes in Patients With the Metabolic Syndrome
High-Dose Treatment With Telmisartan Induces Monocytic Peroxisome Proliferator-Activated Receptor-γ Target Genes in Patients With the Metabolic Syndrome
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DOI：
10.1161/hypertensionaha.111.173542
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发表时间：
2011-10-01
期刊：
影响因子：
8.3
通讯作者：
Kintscher, Ulrich
中科院分区：
文献类型：
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作者：
Baehr, Ilse-Nirmala;Tretter, Patrizia;Kintscher, Ulrich
本研究旨在通过对药物未用药的代谢综合征患者血清IL-6水平和单核细胞PPAR-γ靶基因表达的分析，探讨血管紧张素1型受体阻滞剂替米沙坦的抗炎作用及其对PPAR-γ的激活作用。这是一项为期14周的随机、双盲、安慰剂对照的双中心研究，54名代谢综合征患者服用替米沙坦80 mg/d和替米沙坦160 mg/d。除临床实验室测量外，用动态单核细胞试剂盒负向分离提取外周血单核细胞，在基线和研究结束时使用实时定量RT-PCR评估配体激活的PPARγ靶基因(CD36和CD163)的表达。在这一低风险患者群体中，替米沙坦(80和160毫克)治疗对血清白介素6水平没有显著影响。替米沙坦显著诱导单核细胞PPARγ靶基因CD36的表达(替米沙坦80 mg：2.3+/-1.5倍于安慰剂[P值不显著]；替米沙坦160 mg：3.5+/-0.9倍于安慰剂[P
The present study aimed to explore the anti-inflammatory effects and peroxisome proliferator-activated receptor-gamma (PPAR gamma)-activating properties of the angiotensin type 1 receptor blocker telmisartan by analysis of serum interleukin 6 levels and monocytic PPAR gamma target gene expression in drug-naive patients with the metabolic syndrome. This was a 14-week, randomized, double-blind, placebo-controlled 2-center study with telmisartan 80 mg/d and telmisartan 160 mg/d in 54 patients with the metabolic syndrome. In addition to clinical laboratory measurements, peripheral monocytes were extracted by negative isolation using a Dynal Monocyte kit to evaluate ligand-activated PPAR gamma target gene expression (CD36 and CD163) at baseline and study end using quantitative real-time RT-PCR. In this low-risk patient population, telmisartan (80 and 160 mg) treatment did not significantly affect serum interleukin 6 levels. Expression of the PPAR gamma target gene CD36 in monocytes was markedly induced by telmisartan from baseline to study end (telmisartan 80 mg: 2.3 +/- 1.5-fold change versus placebo [P value not significant]; telmisartan 160 mg: 3.5 +/- 0.9-fold change versus placebo [P