Early-Stage Invasive Breast Cancers: Potential Role of Optical Tomography with US Localization in Assisting Diagnosis
Early-Stage Invasive Breast Cancers: Potential Role of Optical Tomography with US Localization in Assisting Diagnosis
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DOI：
10.1148/radiol.10091237
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发表时间：
2010-08-01
期刊：
影响因子：
19.7
通讯作者：
Tannenbaum, Susan H.
中科院分区：
文献类型：
--
作者：
Zhu, Quing;Hegde, Poornima U.;Tannenbaum, Susan H.
目的：探讨光学断层扫描在近红外(NIR)光谱和超声(US)定位中作为鉴别早期乳腺癌和乳腺良性病变的潜在作用。材料和方法：该方案由机构审查委员会批准，符合HIPAA；所有参与者都签署了知情同意书。178名连续接受超声引导活检的女性(平均年龄52岁；范围21-89岁)使用由共同注册的超声换能器和近红外成像器组成的手持式探头进行成像。联合注册US提供的病变位置用于指导光学成像。测量了两个光学波长的光吸收。通过这项测量，根据计算的总血红蛋白浓度(THB)评估肿瘤血管生成，并与核心活检结果相关联。结果：原位癌2例，T1癌35例，T2-T4癌24例，良性病变114例。Tis-T1组的平均最大和平均THb分别为102.0 mmoL/L 6+/-28.5(标准差)和71.9mmoL/L 6+/-18.8，T2-T4组分别为100.3 mmoL/L 6+/-26.4和67.0mmoL/L 6+/-18.3。良性组平均最高THb为55.1mmoL/L 6+/-22.7，平均最高THb为39.1mmoL/L 614.9。恶性组的平均最大THb和平均THb均显著高于良性组(P
Purpose: To investigate the potential role of optical tomography in the near-infrared (NIR) spectrum with ultrasonographic (US) localization as a means of differentiating early-stage cancers from benign lesions of the breast.Materials and Methods: The protocol was approved by the institutional review boards and was HIPAA compliant; all participants signed an informed consent. One hundred seventy-eight consecutive women (mean age, 52 years; range, 21-89 years) who underwent US-guided biopsy were imaged with a hand-held probe consisting of a coregistered US transducer and an NIR imager. The lesion location provided by coregistered US was used to guide optical imaging. Light absorption was measured at two optical wavelengths. From this measurement, tumor angiogenesis was assessed on the basis of calculated total hemoglobin concentration (tHb) and was correlated with core biopsy results. For patients diagnosed with carcinomas and followed up with subsequent excision, the tHb was correlated with pathologic parameters.Results: There were two in situ carcinomas (Tis), 35 T1 carcinomas, 24 T2-T4 carcinomas, and 114 benign lesions. The mean maximum and mean average tHb of the Tis-T1 group were 102.0 m mol/L 6 +/- 28.5 (standard deviation) and 71.9 m mol/L 6 +/- 18.8, and those of the T2-T4 group were 100.3 m mol/L 6 +/- 26.4 and 67.0 m mol/L 6 +/- 18.3, respectively. The mean maximum and mean average tHb of the benign group were 55.1 m mol/L 6 +/- 22.7 and 39.1 m mol/L 6 14.9, respectively. Both mean maximum and mean average tHb levels were significantly higher in the malignant groups than they were in the benign group (P