Functional interactions among members of the miR-17-92 cluster in lymphocyte development, differentiation and malignant transformation.
Functional interactions among members of the miR-17-92 cluster in lymphocyte development, differentiation and malignant transformation.
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DOI：
10.1016/j.intimp.2015.03.041
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发表时间：
2015-10
影响因子：
5.6
通讯作者：
Xiao C
中科院分区：
文献类型：
--
作者：
Lai M;Xiao C
miR-17-92 簇是多顺反子 miRNA 基因的典型例子。最近，miR-17-92 已成为免疫系统中的多效性调节剂。它的丧失或失调会导致淋巴细胞发育和反应以及淋巴瘤发展的缺陷。尽管簇中的六个单独的 miRNA 是从相同的初级转录本一起表达的，但它们的相对丰度、功能贡献和相互作用在不同的细胞环境中有所不同。
The miR-17–92 cluster is a prototypical example of a polycistronic miRNA gene. Recently, miR-17–92 has emerged as a pleiotropic regulator in immune system. Its loss or deregulation leads to defects in lymphocyte development and response, and lymphoma development. Although the six individual miRNAs of the cluster are expressed together from the same primary transcript, their relative abundance, functional contributions and interactions vary in different cellular contexts.