Effects of aging on capillary number and luminal size in rat soleus and plantaris muscles.
Effects of aging on capillary number and luminal size in rat soleus and plantaris muscles.
复制标题
衰老对大鼠比目鱼肌和跖肌毛细血管数量和管腔大小的影响。
DOI：
10.1097/00005768-200105001-01494
复制
发表时间：
2001
期刊：
影响因子：
--
通讯作者：
T. Mizuta
中科院分区：
文献类型：
--
作者：
Y. Kano;S. Shimegi;H. Furukawa;H. Matsudo;T. Mizuta
为了阐明骨骼肌毛细血管网络的衰老相关变化，我们对幼龄（3月龄）和老年（19月龄）雄性Wistar大鼠的单个肌纤维毛细血管供应和毛细血管管腔大小进行了形态学测量。在灌注固定的比目鱼肌（SOL）和跖肌（PL）的横截面上测定了毛细血管和肌纤维的所有形态计量参数。老肌纤维的大小变化范围较大，主要是由于纤维的肥大和萎缩。然而，在SOL肌肉（年轻大鼠= 7.8 +/- 0.4 vs年老大鼠= 8.1 +/- 0.8）或PL肌肉（年轻大鼠= 6.4 +/- 0.3 vs年老大鼠= 7.0 +/- 0.9）中，单个肌纤维的毛细血管供应，以肌纤维周围毛细血管接触的平均值来评估，并没有随着年龄的增长而改变。幼龄大鼠（SOL = 361.7 +/- 76.0; PL = 264.7 +/- 20.9）和老年大鼠（SOL = 350.2 +/- 61.3; PL = 296.8 +/- 44.9）个体肌纤维面积与肌纤维周围毛细血管接触数之比无显著差异。幼龄大鼠和老年大鼠毛细血管管腔平均直径无统计学差异（SOL，幼龄大鼠= 5.3 +/- 0.5 vs老年大鼠= 5.1 +/- 0.1；PL，幼龄大鼠= 5.0 +/- 0.3 vs老年大鼠= 5.4 +/- 0.2）。综上所述，幼龄和老年大鼠毛细血管供应与肌纤维大小的关系相似，且各毛细血管管腔大小随年龄增长而保持不变。
To clarify aging-related changes in the capillary network in skeletal muscle, we morphometrically examined the capillary supply to individual muscle fibers and capillary luminal size in young (3-month-old) and old (19-month-old) male Wistar rats. All morphometric parameters for capillary and muscle fiber were determined in the cross sections of the perfusion-fixed soleus (SOL) and plantaris (PL) muscles. The range of fiber size was larger in the old muscles because of hypertrophy and atrophy of fibers. However, the capillary supply to individual muscle fibers, assessed as the mean of capillary contacts around a muscle fiber, did not change with aging in SOL muscle (young rats = 7.8 +/- 0.4 vs old rats = 8.1 +/- 0.8) or PL muscle (young rats = 6.4 +/- 0.3 vs old rats = 7.0 +/- 0.9). The ratio of individual muscle fiber area to the number of capillary contacts around a muscle fiber did not differ between young rats (SOL = 361.7 +/- 76.0; PL = 264.7 +/- 20.9) and old rats (SOL = 350.2 +/- 61.3; PL = 296.8 +/- 44.9). The mean capillary luminal diameter did not differ statistically in young and old rats (SOL, young rats = 5.3 +/- 0.5 vs old rats = 5.1 +/- 0.1; PL, young rats = 5.0 +/- 0.3 vs old rats = 5.4 +/- 0.2). In conclusion, the relationship between capillary supply and muscle fiber size is similar for both young and old rats, and the luminal size of each capillary was maintained with advancing age.