Vav family exchange factors: an integrated regulatory and functional view.
Vav family exchange factors: an integrated regulatory and functional view.
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DOI：
10.4161/21541248.2014.973757
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Bustelo XR
中科院分区：
文献类型：
--
作者：
Bustelo XR
Vav家族是位于蛋白酪氨酸激酶下游的一组酪氨酸磷酸化调节的信号转导分子。这些蛋白质的主要功能是作为Rho GT3家族成员的鸟苷酸交换因子（GEF）。此外，它们可以在特定的信号背景下表现出各种催化独立的作用。Vav蛋白对多种细胞谱系的发育和/或效应子功能起着重要的信号传导作用，包括属于免疫、神经和心血管系统的细胞谱系。它们还有助于病理状态，如癌症、免疫相关功能障碍和动脉粥样硬化。在这里，我将提供一个关于这些信号分子的进化，调节和效应特性的综合观点。此外，我将讨论其作为治疗靶点的潜在考虑的利弊。
The Vav family is a group of tyrosine phosphorylation-regulated signal transduction molecules hierarchically located downstream of protein tyrosine kinases. The main function of these proteins is to work as guanosine nucleotide exchange factors (GEFs) for members of the Rho GTPase family. In addition, they can exhibit a variety of catalysis-independent roles in specific signaling contexts. Vav proteins play essential signaling roles for both the development and/or effector functions of a large variety of cell lineages, including those belonging to the immune, nervous, and cardiovascular systems. They also contribute to pathological states such as cancer, immune-related dysfunctions, and atherosclerosis. Here, I will provide an integrated view about the evolution, regulation, and effector properties of these signaling molecules. In addition, I will discuss the pros and cons for their potential consideration as therapeutic targets.