Why is the dog an ideal model for aging research?
Why is the dog an ideal model for aging research?
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DOI：
10.1016/j.exger.2015.08.008
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发表时间：
2015-11-01
影响因子：
3.9
通讯作者：
Greer, Kimberly A.
中科院分区：
文献类型：
--
作者：
Gilmore, Keiva M.;Greer, Kimberly A.
对传统脊椎动物物种与生物老年学调查有关的许多警告，有人建议，最有信息量的模型是：1)检查密切相关的物种，或具有自然发生的寿命变化的同一物种的不同成员，2)已经制定了适当的医疗程序，3)具有良好的注释基因组，4)不需要人工住房，并且可以在被调查时生活在自然环境中，以及5)允许在相对较短的时间内收集大量信息。不出所料，家犬符合提到的每一项标准。狗已经成为评估手术技术和新药的关键模型系统，因为人和狗的条件、治疗方法和治疗反应之间有着惊人的相似性。狗自然可以作为疾病模型进行研究，从而消除了构建人造转基因疾病样本的需要。就像狗为人类的状况和疾病提供了一个自然的模型一样，简单的观察得出结论，狗的衰老表型也与人类相似。基因信息、与GH/IGF-1途径有关的生化信息，以及一些有限的纵向研究，已经开始建立家犬作为衰老模型。虽然我们发现狗确实是研究衰老的模型，而且有许多独立的犬类衰老数据，但还有更多的“开放”领域，适合研究的时机已经成熟。由爱思唯尔公司出版。
With many caveats to the traditional vertebrate species pertaining to biogerontology investigations, it has been suggested that a most informative model is the one which: 1) examines closely related species, or various members of the same species with naturally occurring lifespan variation, 2) already has adequate medical procedures developed, 3) has a well annotated genome, 4) does not require artificial housing, and can live in its natural environment while being investigated, and 5) allows considerable information to be gathered within a relatively short period of time. The domestic dog unsurprisingly fits each criterion mentioned. The dog has already become a key model system in which to evaluate surgical techniques and novel medications because of the remarkable similarity between human and canine conditions, treatments, and response to therapy. The dog naturally serves as a disease model for study, obviating the need to construct artificial genetically modified examples of disease. Just as the dog offers a natural model for human conditions and diseases, simple observation leads to the conclusion that the canine aging phenotype also mimics that of the human. Genotype information, biochemical information pertaining to the GH/IGF-1 pathway, and some limited longitudinal investigations have begun the establishment of the domestic dog as a model of aging. Although we find that dogs indeed are a model to study aging and there are many independent pieces of canine aging data, there are many more "open" areas, ripe for investigation. Published by Elsevier Inc.