Correlation between the regional brain volume and glymphatic system activity in progressive supranuclear palsy.
Correlation between the regional brain volume and glymphatic system activity in progressive supranuclear palsy.
复制标题
进行性核上性麻痹中区域脑容量与类淋巴系统活动之间的相关性。
DOI：
10.1159/000530075
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Matsuda H.
中科院分区：
文献类型：
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作者：
Ota M;Sato N;Takahashi Y;Shigemoto Y;Kimura Y;Nakaya M;Chiba E;Matsuda H.
Tau蛋白在脑内的积聚被认为是导致进行性核上性麻痹（PSP）的原因之一。胶质淋巴系统在十年前被发现是大脑中的废物排放系统，可以促进淀粉样β蛋白和tau蛋白的消除。我们在这里评估胶质淋巴系统的活动和区域脑体积在PSP patients.MethodSubjects之间的关系24例PSP和42名健康参与者进行扩散张量成像（DTI）。我们计算的扩散张量图像分析沿着血管周围空间（DTI-ALPS）指数作为一个代理的胶质淋巴系统的活动和估计的DTI-ALPS指数和区域脑容量之间的关系在PSP患者的全脑和区域的利益分析，包括分析中脑和第三和侧ventricles.ResultsThe DTI-ALPS指数显着降低与PSP患者相比，健康受试者。此外，有显着的相关性之间的DTI-ALPS指数和中脑被盖，脑桥，右额叶，侧脑室在PSP患者的区域脑容量。ConclusionsOur数据表明，DTI-ALPS指数是一个很好的生物标志物PSP，可能是有效的区分PSP从其他神经认知障碍。
IntroductionTau protein accumulation in the brain is thought to be one of the causes of progressive supranuclear palsy (PSP). The glymphatic system was discovered a decade ago as a waste drainage system in the brain that promotes the elimination of amyloid-beta and tau protein. We here evaluated the relationships between glymphatic system activity and regional brain volumes in PSP patients.MethodSubjects were 24 patients with PSP and 42 healthy participants who underwent diffusion tensor imaging (DTI). We computed the diffusion tensor image analysis along the perivascular space (DTI-ALPS) index as a proxy of glymphatic system activity and estimated the relationships between the DTI-ALPS index and regional brain volume in PSP patients by whole-brain and region-of-interest analyses, including analyses of the midbrain and third and lateral ventricles.ResultsThe DTI-ALPS index was significantly lower in patients with PSP compared with healthy subjects. Further, there were significant correlations between the DTI-ALPS index and the regional brain volumes in the midbrain tegmentum, pons, right frontal lobe, and lateral ventricles in patients with PSP.ConclusionsOur data suggest that the DTI-ALPS index is a good biomarker for PSP and might be effective to distinguish PSP from other neurocognitive disorders.