EVALUATION OF NON-SINK DIALYSIS METHODS FOR THE MEASUREMENT OF DRUG RELEASE FROM COLLOIDS - EFFECTS OF DRUG PARTITION
EVALUATION OF NON-SINK DIALYSIS METHODS FOR THE MEASUREMENT OF DRUG RELEASE FROM COLLOIDS - EFFECTS OF DRUG PARTITION
复制标题
DOI：
10.1016/0378-5173(89)90062-8
复制
发表时间：
1989-11-01
影响因子：
5.8
通讯作者：
WASHINGTON, C
中科院分区：
文献类型：
--
作者：
WASHINGTON, C
过去已使用跨膜非漏透析技术来测定药物从胶体制剂中的释放曲线。它表明，在大多数情况下，所获得的结果实际上是独立的释放速率，并且所观察到的释放速率是完全依赖于胶体和其连续相之间的药物的分配系数。它建议，这可能会形成一个有用的方法来测量分散系统中的分配。
The technique of non-sink dialysis across a membrane has been used in the past for determining the release profiles of drugs from colloidal formulations. It is demonstrated that in most cases the results obtained are in fact independent of the release rate, and that the observed release rate is solely dependent on the partition coefficient of the drug between the colloid and its continuous phase. It is suggested that this may form a useful method for measuring partition in disperse systems.