Quantifying glioma cell growth and invasion in vitro
Quantifying glioma cell growth and invasion in vitro
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DOI：
10.1016/j.mcm.2007.02.024
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发表时间：
2008-03-01
影响因子：
--
通讯作者：
Swanson, Kristin R.
中科院分区：
文献类型：
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作者：
Swanson, Kristin R.
神经胶质瘤（最常见的原发性脑肿瘤）的生长和侵袭已经建立了一个数学模型。该模型已被证明与胶质瘤的体内成像研究非常吻合。在这里，我们证明了模型与体外实验数据的一致性。本文提供的分析表明，该模型与已发表的神经胶质瘤细胞在培养中生长和侵袭的观察结果非常吻合。这些体外实验结果支持了该模型在描述实验环境中胶质瘤细胞行为方面的实用性，但也为该模型在体内环境中的应用提供了依据。(c) 2007 Elsevier Ltd.版权所有。
A mathematical model has been developed to describe and quantify the growth and invasion of gliomas ( the most common type of primary brain tumors). The model has already been shown to agree well with in vivo imaging studies of gliomas. Here we demonstrate the model's agreement with in vitro experimental data. The analysis provided in this article demonstrates that the model agrees well with published observations of growth and invasion of gliomas cells in culture. These in vitro results support the model's utility in describing the behavior of glioma cells in experimental settings but also lends credence to the applications of the model to the in vivo setting. (c) 2007 Elsevier Ltd. All rights reserved.