Uniformity detector retinal ganglion cells fire complex spikes and receive only light-evoked inhibition.
Uniformity detector retinal ganglion cells fire complex spikes and receive only light-evoked inhibition.
复制标题
均匀性检测器视网膜神经节细胞发射复杂的尖峰并且仅接收光诱发的抑制。
DOI：
10.1073/pnas.0909621107
复制
发表时间：
2010
影响因子：
11.1
通讯作者：
Vaney,DavidI
中科院分区：
文献类型：
--
作者：
Sivyer,Benjamin;Taylor,WRowland;Vaney,DavidI
Retinal ganglion cells convey information by increasing their firing in response to an optimal visual stimulus or “trigger feature.” However, one class of ganglion cell responds to changes in the visual scene by decreasing its firing. These cells, termed uniformity detectors in the rabbit retina, are encountered only rarely and the synaptic mechanisms underlying their unusual responses have not been investigated. In this study, patch-clamp recordings of uniformity detectors show that the action potentials underlying the maintained firing arise within “complex spikes.” Both ON and OFF visual stimuli elicit only inhibitory synaptic input, the immediate effect of which is to suppress the maintained firing. However, this inhibition also alters the properties of the “renascent” spiking by increasing the amplitude of the spikes within each burst, suggesting that the effect may increase the efficacy of spike propagation and transmission.
