A report from Fukushima: an assessment of bone health in an area affected by the Fukushima nuclear plant incident
A report from Fukushima: an assessment of bone health in an area affected by the Fukushima nuclear plant incident
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DOI：
10.1007/s00774-013-0482-5
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发表时间：
2013-11-01
影响因子：
3.3
通讯作者：
Saito, Yasutoshi
中科院分区：
文献类型：
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作者：
Ishii, Takeaki;Ito, Kazuo;Saito, Yasutoshi
对受福岛核电站事故影响地区的居民的骨骼健康进行了评估。骨质疏松症患者在福岛事件之前曾在索玛中心医院接受过活性维生素D3和/或双膦酸盐治疗，纳入研究对象。对骨转换指标和骨密度的变化进行回顾性分析。所有治疗组的血清骨吸收标志物-I型胶原交联N-端肽水平均降低，而骨形成标志物-骨特异性碱性磷酸酶水平升高。相应地，通过双能X射线骨密度仪估计的骨密度在所有组的腰椎中都有所增加，但只有在两种药物联合治疗的组中才发现股骨近端的骨量增加。从这些参数变化的程度来看，抗骨质疏松治疗看起来有效，与过去观察到的预期效力相当。在现阶段，本研究暗示福岛核事件并未对受影响地区的骨骼健康带来严重风险。
Bone health was assessed for inhabitants of an area affected by the Fukushima nuclear plant incident. Osteoporotic patients, who had been treated with active vitamin D3 and/or bisphosphonate at Soma Central Hospital before the Fukushima incident, were enrolled. Changes in bone turnover markers and bone mineral density were retrospectively analyzed. Serum levels of a bone resorption marker, serum type I collagen cross-linked N-telopeptide were decreased in all the treated groups, whereas those of a bone formation marker, bone-specific alkaline phosphatase, were increased. Accordingly, bone mineral density, estimated by dual-energy X-ray absorptiometry, was increased in the lumbar spine of all groups, but bone mass increase in the proximal femur was detected only in the group treated with the two agents in combination. From the degree of these parameter changes, the antiosteoporotic treatments looked effective and were equivalent to the expected potency of past observations. At this stage, the present study implies that the Fukushima nuclear incident did not bring an acute risk to bone health in the affected areas.