DEPRESSED MOOD AND DEVELOPMENT OF CANCER
DEPRESSED MOOD AND DEVELOPMENT OF CANCER
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DOI：
10.1093/oxfordjournals.aje.a115739
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发表时间：
1990-11-01
影响因子：
5
通讯作者：
COMSTOCK, GW
中科院分区：
文献类型：
--
作者：
LINKINS, RW;COMSTOCK, GW
这项研究是为了确定病前抑郁情绪是否与癌症的发展有关。1971-1974年，在美国马里兰州华盛顿县进行的一项心理健康研究中，有2264名参与者的抑郁量表得分，这些参与者在2-4年后仍无癌症。在12年的随访期间（1975-1987），这些人中有169人被诊断出癌症。虽然在整个研究人群中，抑郁情绪与随后的癌症只有轻微的联系，但在吸烟者中，这种联系要强烈得多。与从不吸烟但没有抑郁情绪的人相比，吸烟水平最高的人患抑郁情绪的相对风险是总体癌症的4.5倍，与吸烟无关的部位患癌症的风险是2.9倍，与吸烟有关的部位患癌症的风险是18.5倍。
This study was undertaken to determine whether premorbid depressed mood is associated with the development of cancer. Scores on the Center for Epidemiologic Studies Depression Scale were available for 2,264 participants in a mental health study conducted in 1971-1974 in Washington County, Maryland [USA], who were still free of cancer 2-4 years later. Over a 12-year follow-up period (1975-1987), 169 cancers were diagnosed among these persons. While there was only a slight association of depressed mood with subsequent cancer among the total study population, the association was much stronger among cigarette smokers. Compared with the risk seen in never smokers without depressed mood, depressed mood at the highest level of smoking was associated with relative risks of 4.5 for total cancer, 2.9 for cancer at sites not associated with smoking, and 18.5 for cancer at sites associated with smoking.