Polymorph generation in capillary spaces: The preparation and structural analysis of a metastable polymorph of nabumetone
Polymorph generation in capillary spaces: The preparation and structural analysis of a metastable polymorph of nabumetone
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DOI：
10.1021/cg0200311
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发表时间：
2002-11-01
影响因子：
3.8
通讯作者：
Childs, SL
中科院分区：
文献类型：
--
作者：
Chyall, LJ;Tower, JM;Childs, SL
在毛细管中进行的萘丁美酮（4-（6-甲氧基-2-萘基）-2-丁酮）的结晶研究产生了亚稳态多晶型物。这种高能量形式的单晶X射线结构，并与已知的低能量形式的结构进行比较。萘丁美酮的亚稳形式在用低能多晶型物研磨或播种时容易转化为固态的低能形式。亚稳形式的不稳定性被认为是由于存在较弱的C-H…0相互作用时相比，更稳定的形式。
Crystallization studies of nabumetone (4-(6-methoxy-2-naphthalenyl)-2-butanone) performed in capillary tubes yielded a metastable polymorph. The single-crystal X-ray structure of this high-energy form is presented and compared to the structure of the known low-energy form. The metastable form of nabumetone readily converts to the low-energy form in the solid state upon grinding or seeding with the low-energy polymorph. The instability of the metastable form is believed to be due to the presence of weaker C-H... 0 interactions when compared to the thermodynamically more stable form.