Synthesis and characterization of a zwitterionic hydrogel blend with low coefficient of friction
Synthesis and characterization of a zwitterionic hydrogel blend with low coefficient of friction
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DOI：
10.1016/j.actbio.2016.09.022
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发表时间：
2016-12-01
影响因子：
9.7
通讯作者：
Blum, Michelle M.
中科院分区：
文献类型：
--
作者：
Osaheni, Allen O.;Finkelstein, Eric B.;Blum, Michelle M.
水凝胶在各种生物医学应用中显示出巨大的潜力。通常，这些仿生材料的性能由于较差的摩擦和磨损性能而受到限制。该手稿提出了一种受自然界中观察到的摩擦学现象启发的方法，用于增强聚（乙烯醇）（PVA）水凝胶的润滑性能。这是通过将 PVA 与不同量的两性离子聚合物聚（[2-（甲基丙烯酰氧基）乙基]二甲基-（3-磺基丙基）氢氧化铵）（pMEDSAH）共混来实现的。我们的结果表明，pMEDSAH 可以作为有效的边界润滑剂，使摩擦系数降低 80% 以上。在保持与纯材料相当的机械和物理性能的同时，实现了摩擦系数的降低。此外，这些两性离子混合物被发现具有细胞相容性。对该系统内的结构与性能关系的分析表明，两性离子聚合物充当边界润滑剂，并通过水合润滑促进摩擦的减少。这种新颖的方法为进一步研究增强生物医学应用水凝胶的摩擦学性能提供了一个有前景的平台。意义声明这项工作的新颖性源于表明两性离子聚合物可以用作极其有效的水凝胶边界润滑剂。这项工作将产生重大的科学影响，因为迄今为止，水凝胶的设计强调机械性能的复制，但为了使这些类型的材料充分用作生物材料，它们必须具有改进的摩擦学和润滑性能，因为忽略表面和边界润滑机制，会使这些潜在的承载替代品与其他自然关节表面不相容，导致结构磨损、失效和损伤健康组织。我们的工作还为这些生物材料的结构特性与功能关系提供了独特的见解，这将引起该期刊读者的极大兴趣。 (C) 2016 Acta Materialia Inc. 由 Elsevier Ltd 出版。保留所有权利。
Hydrogels display a great deal of potential for a wide variety of biomedical applications. Often times the performance of these biomimetic materials is limited due to inferior friction and wear properties. This manuscript presents a method inspired by the tribological phenomena observed in nature for enhancing the lubricious properties of poly(vinyl alcohol) (PVA) hydrogels. This was achieved by blending PVA with various amounts of zwitterionic polymer, poly([2-(methacryloyloxy) ethyl] dimethyl-(3-sulfopropyl) ammonium hydroxide) (pMEDSAH). Our results indicate that pMEDSAH acts as an effective boundary lubricant, allowing for reduction in coefficient of friction by more than 80%. This reduction in friction coefficient was achieved while maintaining comparable mechanical and physical properties to that of the neat material. Also, these zwitterionic blends were found to be cytocompatible. Analysis of the structure to property relationships within this system indicate that the zwitterionic polymer served as a boundary lubricant and promoted a reduction in friction through hydration lubrication. This novel approach provides a promising platform for further investigations enhancing the tribological properties of hydrogels for biomedical applications.Statement of SignificanceThe novelty of this work stems from showing that zwitterionic polymers can be used as an extremely effective hydrogel boundary lubricant. This work will have significant scientific impact because to date, design of hydrogels has emphasized replication of mechanical properties, but in order for these types of materials to be fully utilized as biomaterials it is imperative that they possess improved tribological and lubrication properties, because ignoring the surface and boundary lubrication mechanism, make these potential load-bearing substitutes incompatible with other natural articulating surfaces, leading the constructs to wear, fail, and damage healthy tissue. Our work also provides unique insight to the structure property-function relationships of these biomaterials which will be of great interest to the readership of the journal. (C) 2016 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.