Acid-sensing by carotid body is inhibited by blockers of voltage-sensitive Ca2+ channels
Acid-sensing by carotid body is inhibited by blockers of voltage-sensitive Ca2+ channels
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DOI：
10.1016/s0006-8993(97)00820-2
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发表时间：
1997-09-26
期刊：
影响因子：
2.9
通讯作者：
Lahiri, S
中科院分区：
文献类型：
--
作者：
Roy, A;Rozanov, C;Lahiri, S
通过直接测量体外灌流和灌洗的大鼠和猫颈动脉体的化学感受输出，对膜电位假说进行了研究，该假说认为颈动脉化学感受活性对高碳酸血症的反应是由电压门控Ca2 +通道介导的。我们发现电压门控Ca2 +通道的无机和有机阻断剂抑制了高碳酸血症反应，从而支持了膜电位假说。（C）1997年爱思唯尔科学出版社
The membrane potential hypothesis that the responses to hypercapnia of carotid chemosensory activity is mediated by voltage-gated Ca2+ channels was investigated by measuring directly the chemosensory output from rat and cat carotid bodies, perfused and superfused in vitro. We found that the inorganic and organic blockers of voltage-gated Ca2+ channels suppressed the hypercapnic responses, thereby supporting the membrane potential hypothesis. (C) 1997 Elsevier Science B.V.