A low-cost photoacoustic microscopy system with a laser diode excitation
A low-cost photoacoustic microscopy system with a laser diode excitation
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DOI：
10.1364/boe.5.003053
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发表时间：
2014-09-01
影响因子：
3.4
通讯作者：
Zhu, Quing
中科院分区：
文献类型：
--
作者：
Wang, Tianheng;Nandy, Sreyankar;Zhu, Quing
光声显微镜（PAM）能够绘制生物组织中的微血管网络，并在生物医学应用中表现出巨大的潜力。然而，由于使用笨重且昂贵的脉冲激光源，PAM系统的临床应用受到限制。本文介绍了一种采用脉冲激光二极管激励的低成本光学分辨率 PAM 系统。通过对碳纤维进行成像，该 PAM 系统的横向分辨率估计为 7 μm。对由充满血液的聚乙烯管和小鼠耳朵制成的模型进行成像，以证明该 PAM 系统对生物组织成像的可行性。 (C) 2014年美国光学学会
Photoacoustic microscopy (PAM) is capable of mapping microvasculature networks in biological tissue and has demonstrated great potential for biomedical applications. However, the clinical application of the PAM system is limited due to the use of bulky and expensive pulsed laser sources. In this paper, a low-cost optical-resolution PAM system with a pulsed laser diode excitation has been introduced. The lateral resolution of this PAM system was estimated to be 7 mu m by imaging a carbon fiber. The phantoms made of polyethylene tubes filled with blood and a mouse ear were imaged to demonstrate the feasibility of this PAM system for imaging biological tissues. (C) 2014 Optical Society of America