The influence of age, alcohol consumption, and body build on gonadal function in men.
The influence of age, alcohol consumption, and body build on gonadal function in men.
复制标题
年龄、饮酒量和体型对男性性腺功能的影响。
DOI：
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发表时间：
1980
影响因子：
5.8
通讯作者：
J. Rowe
中科院分区：
文献类型：
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作者：
D. Sparrow;R. Bossé;J. Rowe
在VA的标准老化研究中，对健康筛选的年轻（31-44岁; n = 44）和老年（64-88岁; n = 42）男性参与者的睾酮、双氢睾酮、雌二醇和促性腺激素的基础血浆水平以及睾酮结合能力（与蛋白结合的放射性睾酮百分比）进行了测量。年龄对睾酮[年轻组，4.16 +/- 0.27（SEM）ng/ml;老年组，4.62 +/- 0.32（SEM）ng/ml]或游离睾酮指数[年轻组，2.05 +/- 0.14（SEM）ng/ml;老年组，1.76 +/- 0.11（SEM）ng/ml]没有统计学显著影响。老年组的睾酮结合能力更高（年轻组，50.10 +/- 1.18%（SEM）;老年组，60.10 +/- 1.18%（SEM）; P <0.001）。在研究的两种睾酮代谢产物中，雌二醇不随年龄变化，而老年组的双氢睾酮较低[年轻组，0.25 +/- 0.02（SEM）ng/ml;老年组，0.20 +/- 0.01（SEM）ng/ml; P = 0.03]。FSH水平在老年男性中升高[老年组，92.9 +/- 6.0（SEM）ng/ml;年轻组，61.1 +/- 5.0（SEM）ng/ml; P <0.001]。LH水平不受年龄的显着影响。长期稳定的酒精摄入水平对性腺功能没有影响，通过睾酮水平和游离睾酮指数来估计。体型和激素水平之间的关系的分析表明，雌激素水平最高的男性和最低的男性中，雌雄同体。
Basal plasma levels of testosterone, dihydrotestosterone, estradiol, and gonadotropins and testosterone-binding capacity (percent radioactive testosterone bound to protein) were measured in health carefully screened young (31-44 yr old; n = 44) and older (64-88 yr old; n = 42) male participants in the Normative Aging Study of the V.A. There was no statistically significant effect of age on testosterone [younger group, 4.16 +/- 0.27 (SEM) ng/ml; older group, 4.62 +/- 0.32 (SEM) ng/ml] or the free testosterone index [younger group, 2.05 +/- 0.14 (SEM) ng/ml; older group, 1.76 +/- 0.11 (SEM) ng/ml]. The testosterone-binding capacity was higher in the older group (younger group, 50.10 +/- 1.18% (SEM); older group, 60.10 +/- 1.18% (SEM); P less than 0.001). Of the two products of testosterone metabolism studied, estradiol did not change with age, while dihydrotestosterone was lower [young group, 0.25 +/- 0.02 (SEM) ng/ml; older group, 0.20 +/- 0.01 (SEM) ng/ml; P = 0.03] in the older group. FSH levels were increased among the older men [older group, 92.9 +/- 6.0 (SEM) ng/ml; younger group, 61.1 +/- 5.0 (SEM) ng/ml; P less than 0.001]. LH levels were not significantly influenced by age. There was no effect of level of chronic stable alcohol intake on gonadal function, as estimated by testosterone levels and the free testosterone index. Analysis of the relationship between body build and hormone levels indicated that estradiol levels were highest in gynandromorphic men and lowest in mesomorphic men.