Dopamine D1-like receptor in lateral habenula nucleus affects contextual fear memory and long-term potentiation in hippocampal CA1 in rats
Dopamine D1-like receptor in lateral habenula nucleus affects contextual fear memory and long-term potentiation in hippocampal CA1 in rats
复制标题
外侧缰核中的多巴胺 D1 样受体影响大鼠海马 CA1 的情境恐惧记忆和长时程增强
DOI：
10.1016/j.bbr.2016.12.026
复制
发表时间：
2017-03-15
影响因子：
2.7
通讯作者：
Chen, Yanmei
中科院分区：
文献类型：
--
作者：
Chan, Jiangping;Guan, Xin;Chen, Yanmei
外侧缰核(LHb)在情绪和认知中起着重要作用。最近的实验表明，LHb与海马体具有功能相互作用，在空间学习中发挥重要作用。LHB与中脑单胺能脑区，如腹侧被盖区(VTA)相互联系。然而，LHb中的多巴胺1型受体(D1R)在学习和记忆中的作用尚不清楚。本研究将D1R激动剂或拮抗剂分别注入大鼠双侧LHb。我们发现D1R激动剂和拮抗剂都损害了大鼠情境恐惧记忆的获得。D1R激动剂或拮抗剂还可降低自由活动大鼠海马区CA3CA1区突触的长时程增强，并减弱学习诱导的alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic酸受体(AMPAR)亚单位1(GluA1)在Ser831和Ser845的磷酸化。综上所述，我们的结果提示LHb中D1R的功能障碍影响了海马区的功能。(C)2016爱思唯尔B.V.保留所有权利。
The Lateral Habenula (LHb) plays an important role in emotion and cognition. Recent experiments suggest that LHb has functional interaction with the hippocampus and plays an important role in spatial learning. LHb is reciprocally connected with midbrain monoaminergic brain areas such as the ventral tegmental area (VTA). However, the role of dopamine type 1 receptor (D1R) in LHb in learning and memory is not clear yet. In the present study, D1R agonist or antagonist were administered bilaterally into the LHb in rats. We found that both D1R agonist and antagonist impaired the acquisition of contextual fear memory in rats. D1R agonist or antagonist also impaired long term potentiation (LTP) in hippocampal CA3-CA1 synapses in freely moving rats and attenuated learning induced phosphorylation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor (AMPAR) subunit 1 (GluA1) at Ser831 and Ser845 in hippocampus. Taken together, our results suggested that dysfunction of D1R in LHb affected the function of hippocampus. (C) 2016 Elsevier B.V. All rights reserved.