Temperature-induced reciprocal activation of hippocampal field activity
Temperature-induced reciprocal activation of hippocampal field activity
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DOI：
10.1152/jn.00953.2003
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发表时间：
2004-01-01
影响因子：
2.5
通讯作者：
Blumberg, MS
中科院分区：
文献类型：
--
作者：
Karlsson, KAE;Blumberg, MS
海马神经网络活动在持续的节律（例如，θ）和非周期性群体尖峰（例如，尖波、齿状尖峰）。虽然温度是已知的，以调节各方面的节律性海马活动，鲜为人知的是，关于人口尖峰的发病率的温度的影响。我们在脑温为37 ℃和27 ℃的条件下，使用多位点硅电极记录了脑缺血幼年大鼠（P2-P16）海马沿着CA 1-齿状回轴的自发活动。θ和γ放射性，以及尖波，在37摄氏度检测到，但在27摄氏度没有。相比之下，齿状棘波在37 ℃时很少见，但在27 ℃时其发生率增加了几倍（在27 ℃时最老的幼仔中也出现了癫痫样活动）。在寒冷的大脑中，齿状棘波活动的发生率令人惊讶地增加，这是第一次证明神经元的场模式。此外，这些研究结果表明，脑温度的变化产生系统水平的变化之间的相互作用的海马组件的平衡。
Hippocampal network activity oscillates between sustained rhythms (e.g., theta) and aperiodic population spikes (e.g., sharp waves, dentate spikes). Although temperature is known to modulate various aspects of rhythmic hippocampal activity, little is known regarding the influence of temperature on the incidence of population spikes. We recorded spontaneous hippocampal activity along the CA1-dentate gyrus axis using multisite silicon electrodes in urethanized infant rats (P2-P16) at brain temperatures of 37 and 27degreesC. Theta and gamma activity, as well as sharp waves, were detected at 37degreesC but not at 27degreesC. In contrast, dentate spikes were rare at 37degreesC but their incidence increased several-fold at 27degreesC (epileptiform activity also emerged at 27degreesC in the oldest pups). This surprising increase in the incidence of dentate spike activity in a cold brain represents the first such demonstration for a neuronal field pattern. In addition, these findings indicate that changes in brain temperature produce systems-level shifts in the balance among reciprocally interacting hippocampal components.