Evidence from functional magnetic resonance imaging of crossmodal binding in the human heteromodal cortex
Evidence from functional magnetic resonance imaging of crossmodal binding in the human heteromodal cortex
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DOI：
10.1016/s0960-9822(00)00513-3
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发表时间：
2000-06-01
期刊：
影响因子：
9.2
通讯作者：
Brammer, MJ
中科院分区：
文献类型：
--
作者：
Calvert, GA;Campbell, R;Brammer, MJ
背景：整合来自不同感官的信息可以显著增强对外部刺激的检测和识别。与单模输入相比，语义和/或空间一致的多感官提示加快了识别速度并改善了反应时间。不一致的输入会产生相反的效果，降低性能，减缓反应。这些跨模态处理的行为特征似乎与非人类哺乳动物的上丘和大脑皮层的多感觉细胞的反应特性相似。虽然空间上一致的多感官输入可以产生戏剧性的，通常是倍增的细胞活动增加，但空间上不同的线索往往会导致深刻的反应抑郁。结果：利用功能性磁共振成像（fMRI），我们研究了人类大脑皮层是否可以检测到类似的跨模态整合指数，并且为了合成与刺激身份相关的复杂输入，10名人类受试者暴露于语义一致和不一致的视听语音的不同时期，并单独暴露于每个模态。对匹配和不匹配的视听输入的大脑激活与对两种单峰条件的联合反应进行了对比。该策略确定了左侧颞上沟的异模皮质区域，该区域对匹配的视听输入表现出显著的超加性反应增强，而对不匹配的输入则表现出相应的亚加性反应。结论：这些数据提供了功能磁共振成像证据，证明人类异模态皮层通过收敛性进行跨模态结合。他们进一步提出，反应增强和抑郁可能是在不同神经轴水平上操作的多感觉整合的一般特性，而与感觉输入的组合目的无关。
Background: Integrating information from the different senses markedly enhances the detection and identification of external stimuli. Compared with unimodal inputs, semantically and/or spatially congruent multisensory cues speed discrimination and improve reaction times. Discordant inputs have the opposite effect, reducing performance and slowing responses. These behavioural features of crossmodal processing appear to have parallels in the response properties of multisensory cells in the superior colliculi and cerebral cortex of non-human mammals. Although spatially concordant multisensory inputs can produce a dramatic, often multiplicative, increase in cellular activity, spatially disparate cues tend to induce a profound response depression.Results: Using functional magnetic resonance imaging (fMRI), we investigated whether similar indices of crossmodal integration are detectable in human cerebral cortex, and for the synthesis of complex inputs relating to stimulus identity, Ten human subjects were exposed to varying epochs of Semantically congruent and incongruent audio-visual speech and to each modality in isolation. Brain activations to matched and mismatched audio-visual inputs were contrasted with the combined response to both unimodal conditions. This strategy identified an area of heteromodal cortex in the left superior temporal sulcus that exhibited significant supra-additive response enhancement to matched audio-visual inputs and a corresponding sub-additive response to mismatched inputs.Conclusions: The data provide fMRI evidence of crossmodal binding by convergence in the human heteromodal cortex. They further suggest that response enhancement and depression may be a general property of multisensory integration operating at different levels of the neuroaxis and irrespective of the purpose for which sensory inputs are combined.