Real-time visualization of instantaneous frequency from bubble cavitation using color Doppler ultrasound imaging
Real-time visualization of instantaneous frequency from bubble cavitation using color Doppler ultrasound imaging
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DOI：
10.7567/1347-4065/ab4eb1
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发表时间：
2019-10
影响因子：
1.5
通讯作者：
R. Koda;Toshitaka Nakajima;Hiroki Horiuchi;Y. Yamakoshi
中科院分区：
文献类型：
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作者：
R. Koda;Toshitaka Nakajima;Hiroki Horiuchi;Y. Yamakoshi
声空化发射信号的时间分辨观测对于理解气泡空化动力学和监测超声辅助药物递送系统的声孔效率是重要的。使用这种信号的反向传播的先前方法测量具有高时间分辨率的频率，但需要后处理。我们提出了一种方法，使用彩色多普勒超声获得这些信号的瞬时频率与外部参考信号的相位差。标准的彩色多普勒处理应用于发射和参考信号，以实现实时观察由高强度超声波照射产生的气泡空化。一个正弦波信号被用来确认我们的方法的准确性，估计误差为8.59%。使用两种不同浓度的Sonazoid悬浮液进行实验。在超声波的声压为1.0MPa的情况下，占主导地位的气泡空化的类型在约十个脉冲的照射之前和之后不同。
Time-resolved observations of acoustic cavitation emission signals are important in understanding bubble cavitation dynamics and monitoring sonoporation efficiencies of ultrasound-assisted drug delivery systems. Previous methods using back propagation of such signals measure frequencies with high time resolutions but require post-processing. We propose a method using color Doppler ultrasound to obtain instantaneous frequencies of these signals from the phase differences with an external reference signal. Standard color Doppler processing is applied to both emissions and reference signals to enable real-time observations of bubble cavitation generated by high-intensity ultrasound wave irradiation. A sinusoidal wave signal was used to confirm the accuracy of our method with an estimation error of 8.59%. Experiments were performed using Sonazoid suspensions of two different concentrations. With a sound pressure of 1.0 MPa for the ultrasound wave, the type of bubble cavitation that is dominant is different before and after irradiation of about ten pulses.