The effect of acute superior oblique palsy on torsional optokinetic nystagmus in monkeys.
The effect of acute superior oblique palsy on torsional optokinetic nystagmus in monkeys.
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急性上斜肌麻痹对猴子扭转性视动眼球震颤的影响。
DOI：
10.1167/iovs.07-0989
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发表时间：
2008
影响因子：
4.4
通讯作者：
Zee,DavidS
中科院分区：
文献类型：
--
作者：
Shan,Xiaoyan;Tian,Jing;Ying,HowardS;Walker,MarkF;Guyton,David;Quaia,Christian;Optican,LanceM;Tamargo,RafaelJ;Zee,DavidS
目的.研究获得性上级斜肌麻痹（SOP）和斜视矫正手术对猴扭转性视动性眼震（tOKN）的影响。在2只恒河猴（M1和M2）中，颅内切断滑车神经。对于每只猴，SOP后超过4个月，将同侧下斜肌去神经支配并摘除。对于M2，4个月后，对侧下直肌凹陷2 mm。在单眼观看旋转刺激时诱发tOKN，旋转刺激被投射到动物前方43.5 cm的屏幕上。围绕中心的刺激的角度旋转为40度/秒顺时针或逆时针。结果表明：（1）内旋和外旋时，麻痹眼扭转快相和慢相的振幅和峰值速度均小于正常眼;（2）扭转快相和慢相时，麻痹眼的垂直运动均增大。矫正下斜肌手术后，这两种效果甚至更好。结论。获得性SOP和矫正性下睑肌弱化手术产生了tOKN变化的特征性模式，反映了参与眼球扭转的眼外肌动态特性的改变。tOKN还提供了与传统的Bielschowsky头倾斜测试所提供的信息互补的信息，并且可能有助于区分垂直眼位不正的不同原因。
purpose. To investigate the effects of acquired superior oblique palsy (SOP) and corrective strabismus surgery on torsional optokinetic nystagmus (tOKN) in monkeys.methods. The trochlear nerve was severed intracranially in two rhesus monkeys (M1 and M2). For each monkey, more than 4 months after the SOP, the ipsilateral inferior oblique muscle was denervated and extirpated. For M2, 4 months later, the contralateral inferior rectus muscle was recessed by 2 mm. tOKN was elicited during monocular viewing of a rotating stimulus that was rear projected onto a screen 43.5 cm in front of the animal. Angular rotation of the stimulus about the center was 40 deg/s clockwise or counterclockwise.results. The main findings after trochlear nerve sectioning were (1) the amplitude and peak velocity of torsional quick and slow phases of the paretic eye was less than that in the normal eye for both intorsion and extorsion, and (2) the vertical motion of the paretic eye increased during both torsional slow and quick phases. After corrective inferior oblique surgery, both of these effects were even greater.conclusions. Acquired SOP and corrective inferior oblique-weakening surgery create characteristic patterns of change in tOKN that reflect alterations in the dynamic properties of the extraocular muscles involved in eye torsion. tOKN also provides information complementary to that provided by the traditional Bielschowsky head-tilt test and potentially can help distinguish among different causes of vertical ocular misalignment.
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