Luteolin protects against high fat diet-induced cognitive deficits in obesity mice
Luteolin protects against high fat diet-induced cognitive deficits in obesity mice
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DOI：
10.1016/j.bbr.2014.02.040
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发表时间：
2014-07-01
影响因子：
2.7
通讯作者：
Zhang, Ling
中科院分区：
文献类型：
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作者：
Liu, Yi;Fu, Xiaobin;Zhang, Ling
流行病和实验研究证实，肥胖可导致神经炎症、神经退行性疾病并对认知产生不利影响。尽管对于肥胖对认知能力下降的影响有大量的阐述，但造成肥胖损害的因素仍不清楚。雄性 C57BL/6J 小鼠喂食对照或高脂饮食 (HFD) 16 周，然后随机分为四组，分别接受各自饮食治疗 4 周，其中包括对照饮食 (CD)；控制饮食+木犀草素（CDL）；高脂饮食（HFD）、高脂饮食+木犀草素（HFDL）。木犀草素的剂量为10mg/kg，口服。我们发现，在高脂饮食中添加木犀草素可以显着降低 HFD 小鼠的体重增加、食物摄入量和血浆细胞因子，并改善葡萄糖代谢。重要的是，我们发现木犀草素治疗具有减轻小鼠大脑神经炎症、氧化应激和神经元胰岛素抵抗的作用，使血液脂肪细胞因子水平恢复正常。此外，木犀草素还增加了皮质和海马中脑源性神经营养因子（BDNF）的水平、突触蛋白I（SYP）和突触后密度蛋白95（PSD-95）的作用，从而显着改善了莫里斯水迷宫（MWM）和逐步任务的行为表现。这些结果表明，木犀草素在减轻肥胖引起的 2 型糖尿病和阿尔茨海默病 (AD) 认知障碍方面具有之前未被认识到的潜力。 (C) 2014 Elsevier B.V. 保留所有权利。
The epidemic and experimental studies have confirmed that the obesity can lead to neuroinflammation, neurodegenerative diseases and adversely affect cognition. Despite the numerous elucidations on the impact of obesity on cognition decline, the contributors to the impairments in obesity remain unclear. Male C57BL/6J mice were fed either a control or high-fat diet (HFD) for 16 weeks and then randomized into four groups treated with their respective diets for 4 weeks including control diet (CD); control diet+luteolin (CDL); high-fat diet (HFD), high-fat diet+luteolin (HFDL). The dose of luteolin was 10 mg/kg, oral. We showed that adding luteolin in high-fat diet can significantly reduce body weight gain, food intake and plasma cytokines as well as improving glucose metabolism of mice on HFD. Importantly, we showed that luteolin treatment had the effects of alleviating neuroinflammation, oxidative stress and neuronal insulin resistance in the mouse brain, restored blood adipocytokines level to normal. Furthermore, luteolin increased the level of brain-derived neurotrophic factor (BDNF), the action of synapsin I (SYP) and postsynaptic density protein 95 (PSD-95) in the cortex and hippocampus as to that the behavioral performance in Morris water maze (MWM) and step-through task were significantly improved. These results indicate a previously unrecognized potential of luteolin in alleviating obesity-induced cognitive impairment for type-2 diabetes mellitus and Alzheimer disease (AD). (C) 2014 Elsevier B.V. All rights reserved.